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Showing 1–3 of 3 results
Advanced filters: Author: Eléonore Toufektchan Clear advanced filters

  • P53 is regarded as the guardian of the genome, however it is known that mice with increased p53 activity display characteristics of dyskeratosis congenita. Here the authors show that increased p53 activity leads to the repression of telomere maintenance and DNA repair genes.

    • Sara Jaber
    • Eléonore Toufektchan
    • Franck Toledo
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Missegregated chromosomes that are sequestrated in micronuclei are subject to changes in histone modifications leading to abnormalities in chromatin accessibility that remain long after the chromosomes have been reincorporated into the primary nucleus.

    • Albert S. Agustinus
    • Duaa Al-Rawi
    • Samuel F. Bakhoum
    ResearchOpen Access
    Nature
    Volume: 619, P: 176-183