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Showing 1–5 of 5 results
Advanced filters: Author: Elad Segal Clear advanced filters

  • Statistical analyses of a metagenomics-sequenced human cohort identify a relatively minor role for genetics in determining microbiome composition and show that several human phenotypes are as strongly associated with the gut microbiome as with host genetics.

    • Daphna Rothschild
    • Omer Weissbrod
    • Eran Segal
    Research
    Nature
    Volume: 555, P: 210-215

  • Experimental determination of the secondary structure of RNA molecules has usually been carried out on a case-by-case basis. Now, however, a deep-sequencing approach has been used to profile the secondary structure of 3,000 distinct messenger RNA transcripts from Saccharomyces cerevisiae. The results provide interesting hints about the role of secondary structure in protein translation, and set the stage for the examination of how such structures can change in response to environmental conditions.

    • Michael Kertesz
    • Yue Wan
    • Eran Segal
    Research
    Nature
    Volume: 467, P: 103-107

  • Eitan et al. discovered genetic variants in the 3′UTR for the gene encoding IL-18 receptor that protect against ALS. The variant 3′UTR destabilizes the mRNA and dampens microglia NF-κB signaling and neurotoxicity, thus emphasizing the value of noncoding genetic association studies.

    • Chen Eitan
    • Aviad Siany
    • Eran Hornstein
    Research
    Nature Neuroscience
    Volume: 25, P: 433-445