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Showing 1–2 of 2 results
Advanced filters: Author: Eleanor Valenzi Clear advanced filters

  • Chromatin accessibility dynamics causally influence changes in gene expression levels, but these fluctuations may not be directly coupled over time. Here, authors develop computational causal framework HALO, examining epigenetic plasticity and gene regulation dynamics in single-cell multi-omic data.

    • Haiyi Mao
    • Minxue Jia
    • Panayiotis V. Benos
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Assessing systemic sclerosis (SSc) disease activity is challenging, and improved outcome measures are needed. This Review describes clinical and biochemical outcome measures of distinct features of SSc, with an emphasis on the dermatological manifestations and interstitial lung disease, including insights into biomarkers gained from single-cell RNA sequencing.

    • Robert Lafyatis
    • Eleanor Valenzi
    Reviews
    Nature Reviews Rheumatology
    Volume: 18, P: 527-541