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Showing 1–18 of 18 results
Advanced filters: Author: Eleftherios P. Diamandis Clear advanced filters

  • Eleftherios P. Diamandis considers when to retire.

    • Eleftherios P. Diamandis
    News
    Nature
    Volume: 530, P: 121

  • Some researchers may recoil from metrics-based assessment. But they should know how others are keeping score, say Maria Pavlou and Eleftherios P. Diamandis.

    • Maria Pavlou
    • Eleftherios P. Diamandis
    News
    Nature
    Volume: 478, P: 419

  • Technologies such as mass spectrometry, and protein and DNA arrays, have enabled simultaneous examination of thousands of proteins and genes, giving opportunities to identify distinguishing signatures for cancer diagnosis and classification and prediction of therapeutic response. The authors provide an overview of how the current cancer biomarkers were discovered and their associated limitations, discuss the utilization of these emerging technologies, and review their potential to revolutionize biomarker discovery.

    • Vathany Kulasingam
    • Eleftherios P Diamandis
    Reviews
    Nature Clinical Practice Oncology
    Volume: 5, P: 588-599

  • Despite widespread interest, few serum biomarkers have been introduced to the clinic over the past 20 years. Will a global biomarker discovery platform that mines all possible sources for biomarkers be more useful in the search for promising ovarian cancer biomarkers?

    • Vathany Kulasingam
    • Maria P. Pavlou
    • Eleftherios P. Diamandis
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 371-378

  • Seminal plasma is a potential source of biomarkers of male reproductive system disorders. Drabovich et al. describe the development of seminal plasma proteomics and the progress towards the clinical use of biomarkers of male infertility and prostate cancer.

    • Andrei P. Drabovich
    • Punit Saraon
    • Eleftherios P. Diamandis
    Reviews
    Nature Reviews Urology
    Volume: 11, P: 278-288

  • Members of the family of kallikrein (KLK)-related proteases are found in various tissues — including the airway, prostate and brain — and have a wide range of functions. The authors describe the roles of KLKs in health and disease, and highlight the small-molecule, peptide-based, protein-based, antibody-based and immunotherapeutic strategies that are being used to target KLKs in certain diseases.

    • Ioannis Prassas
    • Azza Eissa
    • Eleftherios P. Diamandis
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 183-202

  • B cells are playing an active role in shaping the tumour immune microenvironment and the anti-tumour immune response in melanomas. Here authors show that intra-tumoral B cells are aberrantly activated and produce antibodies that are potentially autoreactive.

    • Silvia Crescioli
    • Isabel Correa
    • Sophia N. Karagiannis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Cardiac glycosides, a diverse family of naturally derived compounds that inhibit Na+/K+-ATPase, have been used for many years for the treatment of heart failure and atrial arrhythmia. This article discusses recent evidence highlighting additional signal transduction roles for Na+/K+-ATPase, and associated potential new therapeutic appplications for glycoside-based drugs in a range of diseases — most notably cancer, for which the first generation of such agents are currently in clinical trials.

    • Ioannis Prassas
    • Eleftherios P. Diamandis
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 926-935

  • Proteomic and biochemical studies on cervical-vaginal fluid (CVF) have revealed that it contains several members of the tissue kallikrein-related peptidase (KLK) family. The roles of KLKs in the lower female reproductive system are not fully understood. In this Review, Muytjens and colleagues discuss the putative roles of KLKs in vaginal fluid and how increased understanding of their function could result in new diagnostic and therapeutic modalities.

    • Carla M. J. Muytjens
    • Stella K. Vasiliou
    • Eleftherios P. Diamandis
    Reviews
    Nature Reviews Urology
    Volume: 13, P: 596-607

    • Vathany Kulasingam
    • Ioannis Prassas
    • Eleftherios P. Diamandis
    CorrespondenceOpen Access
    npj Precision Oncology
    Volume: 1, P: 1-4

  • Proteinases orchestrate many processes in inflammatory arthritis, but their ability to signal via proteolytically activated receptors is often overlooked. This Review provides an overview of proteinases and their receptors in inflammatory arthritis, alongside suggestions for therapeutically targeting these pathways.

    • Katerina Oikonomopoulou
    • Eleftherios P. Diamandis
    • Vinod Chandran
    Reviews
    Nature Reviews Rheumatology
    Volume: 14, P: 170-180