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Showing 1–3 of 3 results
Advanced filters: Author: Elena E. Grintsevich Clear advanced filters

  • Grintsevich et al. discover that the redox enzyme Mical oxidizes F-actin to promote binding of the F-actin-severing protein cofilin, and that the synergy of Mical and cofilin is necessary and sufficient for F-actin disassembly in Drosophila.

    • Elena E. Grintsevich
    • Hunkar Gizem Yesilyurt
    • Emil Reisler
    Research
    Nature Cell Biology
    Volume: 18, P: 876-885

  • Actin-based structures in cells and tissues are built and maintained through a poorly understood balance between assembly and disassembly. Here, our findings provide insights into how factors known to promote these opposing effects dynamically integrate to shape cells and tissue systems.

    • Elena E. Grintsevich
    • Giasuddin Ahmed
    • Jonathan R. Terman
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibility to cofilin-induced severing in the presence of inorganic phosphate.

    • Elena E. Grintsevich
    • Peng Ge
    • Emil Reisler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10