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Showing 1–2 of 2 results
Advanced filters: Author: Elena López-Knowles Clear advanced filters

  • Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor responders have more mutations than good responders and also more frequently harbour p53 mutations.

    • Pascal Gellert
    • Corrinne V. Segal
    • Peter Donnelly
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Francisco Real and colleagues report exome sequencing in urothelial bladder tumors. They show that STAG2, a subunit of the cohesin complex, is recurrently mutated and provide evidence that STAG2 loss does not lead to increases in aneuploidy.

    • Cristina Balbás-Martínez
    • Ana Sagrera
    • Francisco X Real
    Research
    Nature Genetics
    Volume: 45, P: 1464-1469