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CD103^–CD8⁺ T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling

Neuroimmune communication in Alzheimer’s disease (AD) is poorly understood. Here, the authors show that CD103–CD8+ resident memory T cells induce neurotoxicity and neuroinflammation in AD via the granzyme K–PAR-1 axis.

Eleonora Terrabuio
Enrica Caterina Pietronigro
Gabriela Constantin
ResearchOpen Access24 Sept 2025
Nature Communications

Volume: 16, P: 1-24
Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

Neutrophils infiltrate the CNS and promote Alzheimer's disease–like pathology and memory loss.

Elena Zenaro
Enrica Pietronigro
Gabriela Constantin
Research27 Jul 2015
Nature Medicine

Volume: 21, P: 880-886
Regulation of leukocyte recruitment by the long pentraxin PTX3

Leukocytes enter inflamed tissues by initiating selectin-dependent rolling on reactive endothelia. Mantovani and colleagues show that the long pentraxin PTX3 competes for P-selectin and acts to limit neutrophil extravasation.

Livija Deban
Remo Castro Russo
Alberto Mantovani
Research07 Mar 2010
Nature Immunology

Volume: 11, P: 328-334
Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease

Enrica Pietronigro
Elena Zenaro
Gabriela Constantin
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-15