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Showing 1–24 of 24 results
Advanced filters: Author: Eli Pikarsky Clear advanced filters

  • How the same type of cell can form different kinds of tumour isn’t always clear. The discovery that cancer subtype in mice is influenced by the type of cell death occurring in the microenvironment provides some insight.

    • Eli Pikarsky
    News & Views
    Nature
    Volume: 562, P: 45-46

  • It is unclear how resident p16-expressing senescent cells affect the propensity of tissues to develop cancer. Here, the authors show that chronic p16 expression in the mouse epidermis causes hyperplasia and dysplasia through Wnt-mediated paracrine stimulation of proliferating keratinocytes, and can contribute to tumour formation.

    • Narmen Azazmeh
    • Benjamin Assouline
    • Ittai Ben-Porath
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • DNA demethylation is known to be critical for the development and function of many tissues. Here the authors show that it is also required for intestinal lineage differentiation, and that mice lacking DNA demethylases have altered microbiomes and a predisposition to inflammation.

    • Ihab Ansari
    • Llorenç Solé-Boldo
    • Yehudit Bergman
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Predicting an individual's response to therapy is an important goal for precision medicine. Here, the authors use an algorithm that takes into account the interaction type and directionality of signalling pathways in protein–protein interactions and find that their pathway analysis can predict essential genes, which may be a target for therapy.

    • Rotem Ben-Hamo
    • Adi Jacob Berger
    • Ravid Straussman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • A comparison of DNA methylation patterns between conventionally raised and germ-free mice shows that the presence of a commensal microbiota induces methylation changes at regulatory elements in a subset of genes that are important for intestinal homeostasis.

    • Ihab Ansari
    • Günter Raddatz
    • Yehudit Bergman
    Research
    Nature Microbiology
    Volume: 5, P: 610-619

  • In two mouse models of intestinal cancer, mutant p53 has an oncogenic effect in the distal gut but a tumour-suppressive effect in the proximal gut, and these opposing properties are determined by the gut microbiome.

    • Eliran Kadosh
    • Irit Snir-Alkalay
    • Yinon Ben-Neriah
    Research
    Nature
    Volume: 586, P: 133-138

  • Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver.

    • Yitzhak Reizel
    • Ofra Sabag
    • Howard Cedar
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Normal gut–immune system homeostasis requires interactions among epithelial cells, lymphocytes and host microflora. Ben-Neriah and colleagues show that defined microRNA expression in the gut mucosa is also important for maintaining gut integrity and homeostasis.

    • Moshe Biton
    • Avi Levin
    • Yinon Ben-Neriah
    Research
    Nature Immunology
    Volume: 12, P: 239-246

  • Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is one of the leading causes of cancer-related death in the world. This Primer summarizes the current knowledge on the epidemiology, pathogenetic mechanisms and diagnosis of HCC and provides an update on key advancements in the management of this disease.

    • Josep M. Llovet
    • Robin Kate Kelley
    • Richard S. Finn
    Reviews
    Nature Reviews Disease Primers
    Volume: 7, P: 1-28

  • Patients with early stage hepatocellular carcinoma typically undergo resection, liver transplantation or local ablation; however, 30–50% will have disease recurrence at 3 years. The authors of this Review describe the tumour immune microenvironment and mechanism of action of immunotherapies, and discuss the available evidence from phase II/III trials of neoadjuvant and adjuvant treatment approaches in this setting.

    • Josep M. Llovet
    • Roser Pinyol
    • Richard S. Finn
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 21, P: 294-311

  • Immunotherapy is revolutionizing the treatment of many cancers and hepatocellular carcinoma (HCC) is no exception. This Review describes the heterogeneous immune microenvironments of HCC as well as their links with the various aetiologies underlying this malignancy and with response or resistance to immunotherapies. In addition, the authors provide an overview of the current landscape of clinical trials evaluating immunotherapies across all stages of HCC.

    • Josep M. Llovet
    • Florian Castet
    • Richard S. Finn
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 19, P: 151-172

  • This study shows, via a mouse model of intestinal cancer, that in the absence of CKIα, the loss of p53 dramatically enhances tumour progression and metastasis. p53 is shown to normally limit cancer cell invasion via the regulation of p21 and a set of invasion genes that include Prox1. This study adds important insights to the emerging picture that during tumour development the p53 tumour suppressor gene not only controls cell death and proliferation but also metastasis.

    • Ela Elyada
    • Ariel Pribluda
    • Yinon Ben-Neriah
    Research
    Nature
    Volume: 470, P: 409-413

  • Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and has well-known risk factors, including cirrhosis and viral hepatitis. Here, Llovet and colleagues discuss the challenges and recent advances in HCC molecular characterization, diagnosis and management.

    • Josep M. Llovet
    • Jessica Zucman-Rossi
    • Gregory Gores
    Reviews
    Nature Reviews Disease Primers
    Volume: 2, P: 1-23

  • Primary liver cancer, of which hepatocellular carcinoma is the most common form, is the second leading cause of cancer-related death. Heikenwalder and colleagues review the important inflammatory component underlying hepatocellular carcinoma and consider potential directions for therapy.

    • Marc Ringelhan
    • Dominik Pfister
    • Mathias Heikenwalder
    Reviews
    Nature Immunology
    Volume: 19, P: 222-232