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TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength

Anti-tumor functions of low-avidity T cells are often suboptimal. Here the authors show that genetic disruption of TIGIT in TCR-engineered T cells enhances their anti-tumor activity against pancreatic and other gastrointestinal cancers by increasing TCR signal strength.

Martina Spiga
Alessia Potenza
Chiara Bonini
ResearchOpen Access08 Jan 2026
Nature Communications

Volume: 17, P: 1-19
High-resolution analysis of the human T-cell receptor repertoire

Immune system diversity is generated by V(D)J recombination, leading to clonal T-cell lineages. Here the authors investigate the events leading to T-cell diversity through the use of a modified PCR technique combined with deep sequencing.

Eliana Ruggiero
Jan P. Nicolay
Christof von Kalle
ResearchOpen Access01 Sept 2015
Nature Communications

Volume: 6, P: 1-7
Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their circulating counterpart, but share a common origin with intratumoral antigen-experienced conventional T cells.

Maria Xydia
Raheleh Rahbari
Philipp Beckhove
ResearchOpen Access18 Feb 2021
Nature Communications

Volume: 12, P: 1-18
Epigenetic checkpoints regulate the fate and function of CAR-T cells

T cells exist in many functional states, and dynamic transitions from one state to another affect the outcome of adoptive T cell therapy. FOXP1 and KLF2 are now identified as transcriptional regulators of the stemness of CD8⁺ CAR-T cells and the bifurcation of stem-like CD8⁺ CAR-T cells into effector and exhausted subsets, respectively.

Monica Casucci
Chiara Bonini
Eliana Ruggiero
News & Views02 Jan 2024
Nature Immunology

Volume: 25, P: 4-6
Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Martina Musella
Andrea Guarracino
Antonella Sistigu
Amendments and CorrectionsOpen Access17 Sept 2024
Nature Immunology

Volume: 25, P: 2166
Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Amendments and Corrections01 Apr 2018
Nature Medicine

Volume: 24, P: 526
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Type I interferons have been described to have protumor or antitumor functions depending on context. Here the authors show a protumor function for type I interferons in that they promote cancer stem cells by upregulating the chromatin remodeling factor KDM1B.

Martina Musella
Andrea Guarracino
Antonella Sistigu
ResearchOpen Access24 Aug 2022
Nature Immunology

Volume: 23, P: 1379-1392
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells precede and potentially predict the relapse.

Maddalena Noviello
Francesco Manfredi
Chiara Bonini
ResearchOpen Access25 Mar 2019
Nature Communications

Volume: 10, P: 1-15
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.

Nimitha R Mathew
Francis Baumgartner
Robert Zeiser
Research12 Feb 2018
Nature Medicine

Volume: 24, P: 282-291
Prevention and treatment of relapse after stem cell transplantation by cellular therapies

Fred Falkenburg
Eliana Ruggiero
Hans Jochem Kolb
Reviews24 May 2018
Bone Marrow Transplantation

Volume: 54, P: 26-34

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