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Showing 1–2 of 2 results
Advanced filters: Author: Elina Erikson Clear advanced filters

  • γδ T cells are unique T lymphocytes with cytotoxic functions, targeting infections and tumours. Here authors show that the target killing function of γδ T cells is tightly regulated at the level of the availability of lytic molecules granzyme B and perforin.

    • Patrick A. Sandoz
    • Kyra Kuhnigk
    • Björn Önfelt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Resting CD4+ T cells are resistant to HIV-1 infection, but the underlying reasons for this lack of permissiveness have not been clear. Oliver Fackler and colleagues now report that SAMHD1, the deoxynucleoside triphosphate triphosphohydrolase responsible for restriction of HIV-1 infection in myeloid cells, also restricts infection of resting CD4+ T cells. The findings shed new light on the mechanisms of cellular and molecular regulation of HIV-1 infection.

    • Hanna-Mari Baldauf
    • Xiaoyu Pan
    • Oliver T Keppler
    Research
    Nature Medicine
    Volume: 18, P: 1682-1688