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CDH1 germline variants are enriched in patients with colorectal cancer, gastric cancer, and breast cancer

Elio Adib
Talal El Zarif
Guru Sonpavde
ResearchOpen Access23 Dec 2021
British Journal of Cancer

Volume: 126, P: 797-803
Germline variants associated with toxicity to immune checkpoint blockade

A genome-wide association study in large cohorts of patients with different types of cancer treated with immune checkpoint inhibitors identifies genetic variants associated with immune-related adverse events.

Stefan Groha
Sarah Abou Alaiwi
Alexander Gusev
Research16 Dec 2022
Nature Medicine

Volume: 28, P: 2584-2591
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma

The epigenomic landscape of renal cell carcinoma (RCC) remains to be explored. Here, integrative epigenomic analysis of primary human RCC samples and RCC GWAS risk SNPs identifies transcription-factor specific subtypes and enrichment of risk variants in allelically-imbalanced peaks.

Amin H. Nassar
Sarah Abou Alaiwi
Matthew L. Freedman
ResearchOpen Access21 Jan 2023
Nature Communications

Volume: 14, P: 1-16