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Showing 1–4 of 4 results
Advanced filters: Author: Elisa M. Wecht Clear advanced filters

  • Alternative lengthening of telomeres (ALT) is associated with a poor outcome in neuroblastoma. Here, the authors find that ALT is associated with mutated ATRX and/or reduced protein abundance, frequent telomeric repeat loci and heterochromatic telomeric chromatin.

    • Sabine A. Hartlieb
    • Lina Sieverling
    • Frank Westermann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Alborzinia et al. report that MYCN-amplified neuroblastoma undergoes ferroptosis in the absence of intracellular cysteine, suggesting a combination of cysteine depletion and concomitant GPX4 inactivation as a potential therapeutic approach.

    • Hamed Alborzinia
    • Andrés F. Flórez
    • Frank Westermann
    ResearchOpen Access
    Nature Cancer
    Volume: 3, P: 471-485

  • A single-cell transcriptomic analysis of neuroblastomas and healthy adrenal glands defines cell types and lineage trajectories during different developmental stages. Comparisons with the transcriptomes of neuroblastoma cells show that their transcriptomes most closely resemble those of developing neuroblasts of the adrenal gland.

    • Selina Jansky
    • Ashwini Kumar Sharma
    • Frank Westermann
    Research
    Nature Genetics
    Volume: 53, P: 683-693

  • Westermann and colleagues define four subtypes of neuroblastoma based on super-enhancer profiles in primary patient samples, which could be linked to distinct clinical outcomes and cell identity characteristics.

    • Moritz Gartlgruber
    • Ashwini Kumar Sharma
    • Frank Westermann
    Research
    Nature Cancer
    Volume: 2, P: 114-128