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Showing 1–2 of 2 results
Advanced filters: Author: Elisa Vergari Clear advanced filters
  • Somatostatin is secreted by delta cells and inhibits insulin and glucagon secretion. Here Vergari et al. demonstrate a mechanism for somatostatin secretion that is dependent on decreased extracellular potassium and increased intracellular sodium levels, and is altered in islets from patients with diabetes.

    • Elisa Vergari
    • Geoffrey Denwood
    • Linford J. B. Briant
    Research
    Nature Metabolism
    Volume: 2, P: 32-40
  • Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action ameliorates this effect.

    • Elisa Vergari
    • Jakob G. Knudsen
    • Patrik Rorsman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11