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A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion

Galectin-3 is a sugar-binding protein that can inhibit antitumour cytotoxic immunity. Here the authors show that Galectin-3 expressed by tumour cells inhibits LFA-1 on cytotoxic lymphocytes, impairing immunological synapse formation, IFNg secretion, and target cell killing.

Anne-Elisabeth Petit
Nathalie Demotte
Pierre van der Bruggen
ResearchOpen Access22 Jul 2016
Nature Communications

Volume: 7, P: 1-15
New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile

Myriam Ruault
Pierre van der Bruggen
Albertina De Sario
Research03 Dec 2002
European Journal of Human Genetics

Volume: 10, P: 833-840
The effects of probiotics on risk and time preferences

Aline M. Dantas
Alexander T. Sack
Teresa Schuhmann
ResearchOpen Access15 Jul 2022
Scientific Reports

Volume: 12, P: 1-10

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