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Showing 1–4 of 4 results
Advanced filters: Author: Elisabeth Drucker Clear advanced filters

  • Omnivores like bears can switch between plant and animal diets, potentially helping them respond to changing conditions. By combining modern and fossil data, this study shows that bears shift toward carnivory in harsher climates and toward herbivory in more productive environments.

    • Jörg Albrecht
    • Hervé Bocherens
    • Nuria Selva
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodose neurons and enterocytes in a paracrine manner in vitro.

    • Van B. Lu
    • Juraj Rievaj
    • Frank Reimann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.

    • Kerstin Holzer
    • Alessandro Ori
    • Stephan Singer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Helga Ellingsgaard et al. show that secretion of interleukin-6 by muscle in response to exercise, or injection of recombinant protein, increases the expression of the incretin GLP-1 by both intestinal cells and by pancreatic alpha cells, thus potentiating insulin release and improving glycemic control. These results identify a new endocrine loop linking energy demands to homeostatic control while also suggesting further targets for type 2 diabetes therapy.

    • Helga Ellingsgaard
    • Irina Hauselmann
    • Marc Y Donath
    Research
    Nature Medicine
    Volume: 17, P: 1481-1489