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Showing 1–4 of 4 results
Advanced filters: Author: Elisavet Serti Clear advanced filters

  • Teplizumab is clinically approved for delaying the onset of type 1 diabetes, with the responses affected by EBV serology status. Here the authors pursue immune profiling of EBV+ or EBV- participants before and after teplizumab treatment to find more pronounced immune modulation in treated EBV+ individuals to hint a cellular mechanism for this EBV effect.

    • Ana Lledó-Delgado
    • Paula Preston-Hurlburt
    • Kevan C. Herold
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Most efforts to examine islet antigen-reactive T cells in type-1 diabetes have been limited to peripheral blood. In this study, the authors examine the T cell receptor (TCR) repertoire of insulin antigen-reactive T cells from peripheral blood from patients with type-1 diabetes as well as pancreata from deceased donors.

    • Peter S. Linsley
    • Maki Nakayama
    • Karen Cerosaletti
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Autoreactive T cells are subject to continuous antigenic stimulation yet sustain their autoreactive functionality. Youngblood and colleagues examine type 1 diabetes systems to show that a pool of autoreactive CD8+ T cells exhibits a stem cell–like signature that facilitates their durable activity.

    • Hossam A. Abdelsamed
    • Caitlin C. Zebley
    • Ben Youngblood
    Research
    Nature Immunology
    Volume: 21, P: 578-587

  • RNA-sequencing data from NK-like CD57+ and PD-1+ CD8+ exhausted-like T cell populations linked to beneficial immunotherapy response in autoimmune patients suggest shared clonal relationships with each other and with common precursor populations.

    • Erin M. Witkop
    • Kirsten Diggins
    • Peter S. Linsley
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-14