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Showing 1–7 of 7 results
Advanced filters: Author: Elissa P. Lei Clear advanced filters

  • Long-range looping of an enhancer to a promoter (E-P looping) is a key feature of gene activation; thus, regulation of E-P looping could serve as an effective strategy to precisely control gene expression. Here the authors propose the Drosophila chromatin insulator antagonist Shep represses expression of genes during neuronal maturation by preventing E-P looping.

    • Dahong Chen
    • Catherine E. McManus
    • Elissa P. Lei
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders.

    • Indira Bag
    • Shue Chen
    • Elissa P. Lei
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced silencing complex (RISC) to promote heterochromatin formation and transcriptional silencing.

    • Seung Kyu Lee
    • Yutong Xue
    • Weidong Wang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • This study reports a global analysis of binding sites for over 200 RNA-binding proteins (RBPs) from 24 species; conserved RNA-binding motifs are identified, and their analysis allows prediction of interaction sites based on the sequence of the RNA-binding domain alone.

    • Debashish Ray
    • Hilal Kazan
    • Timothy R. Hughes
    Research
    Nature
    Volume: 499, P: 172-177

  • Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds and structures, including the nuclear lamina at the nuclear edge, and nucleoli located more internally within the nucleoplasm. Recently, great effort has been made to understand the intricacies of 3D genome organization and its relevance to genomic and nuclear function. Over the years, many concepts, mathematical models, visual and biochemical methods, and analysis pipelines have been presented to study various aspects of this organization in a multidisciplinary manner, such as is also reflected within this collection.

    • Asli Silahtaroglu
    • Joanna M. Bridger
    • Elissa P. Lei
    EditorialOpen Access
    Scientific Reports
    Volume: 12, P: 1-2