Nature Search

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

Elizabeth M. Simpson
Carol C. Linder
John J. Sharp
Research01 May 1997
Nature Genetics

Volume: 16, P: 19-27
The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization

Elizabeth A Slee
Sébastien Gillotin
Xin Lu
Research18 Oct 2004
Oncogene

Volume: 23, P: 9007-9016
ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis

The early embryo maintains its structure in the face of large mechanical stresses during morphogenesis. Here they show that ASPP2 acts to preserve epithelial integrity in regions of high apical tension during early development.

Christophe Royer
Elizabeth Sandham
Shankar Srinivas
ResearchOpen Access17 Feb 2022
Nature Communications

Volume: 13, P: 1-19
Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis

Elizabeth A. Slee
Xin Lu
ResearchOpen Access31 Oct 2013
Scientific Reports

Volume: 3, P: 1-6
Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

In a new study including 200 families who experienced perinatal death, adding genomic analyses to standard autopsies improved the identification of underlying pathogenic causes and informed genetic counseling.

Alicia B. Byrne
Peer Arts
Hamish S. Scott
ResearchOpen Access19 Jan 2023
Nature Medicine

Volume: 29, P: 180-189
A complex barcode underlies the heterogeneous response of p53 to stress

The tumour suppressor p53 integrates incoming stress signals to prevent malignant progression by inducing cell responses such as apoptosis and senescence. The specific response, coordinated by p53 post-translational modifications and the availability of p53 cofactors, determines the appropriate cellular fate.

Fiona Murray-Zmijewski
Elizabeth A. Slee
Xin Lu
Reviews01 Sept 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 702-712
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

The International Multiple Sclerosis Genetics Consortium reports the discovery of 48 new susceptibility variants for multiple sclerosis through targeted follow-up of immune-related loci. They also report fine mapping of association signals at established susceptibility loci and provide insights into the immune system processes underlying this disease.

Ashley H Beecham
Nikolaos A Patsopoulos
Jacob L McCauley
Research29 Sept 2013
Nature Genetics

Volume: 45, P: 1353-1360
p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer

Paul Miller
Elliot H. Akama-Garren
Xin Lu
ResearchOpen Access03 Jun 2023
Cell Death & Differentiation

Volume: 30, P: 1619-1635
Regulation of immunological tolerance by the p53-inhibitor iASPP

Elliot H. Akama-Garren
Paul Miller
Xin Lu
ResearchOpen Access06 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-16
Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders

Zinaida Dedeić
Gopinath Sutendra
Xin Lu
Research19 Jan 2018
Cell Death & Differentiation

Volume: 25, P: 1289-1303
Author Correction: Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

Alicia B. Byrne
Peer Arts
Hamish S. Scott
Amendments and CorrectionsOpen Access10 Jul 2023
Nature Medicine

Volume: 30, P: 302
Pathogenic copy number variants that affect gene expression contribute to genomic burden in cerebral palsy

Mark A. Corbett
Clare L. van Eyk
Jozef Gecz
ResearchOpen Access14 Dec 2018
npj Genomic Medicine

Volume: 3, P: 1-9
Author Correction: Pathogenic copy number variants that affect gene expression contribute to genomic burden in cerebral palsy

Mark A. Corbett
Clare L. van Eyk
Jozef Gecz
Amendments and CorrectionsOpen Access31 May 2019
npj Genomic Medicine

Volume: 4, P: 1
ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome

J Zak
V Vives
X Lu
Research22 Jul 2016
Cell Death & Differentiation

Volume: 23, P: 1973-1984
To die or not to die: how does p53 decide?

Elizabeth A Slee
Daniel J O'Connor
Xin Lu
Reviews12 Apr 2004
Oncogene

Volume: 23, P: 2809-2818

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