Cancer vaccines are frequently designed to increase the immune response toward one or more of the few known tumor-associated antigens (TAAs). Kottke et al. describe an alternate approach to enhancing anti-tumor immune responses without the need for identification of specific TAAs. They show that systemic delivery of a vesicular stomatis virus–based cDNA library derived from normal tissue induces immune responses that impede growth of tumors of the same tissue type in mice.
- Timothy Kottke
- Fiona Errington
- Richard Vile
