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Showing 1–6 of 6 results
Advanced filters: Author: Elizabeth J. Tarling Clear advanced filters

  • The genetic determinants of sex-specific differences in obesity are still incompletely understood. Here, the authors demonstrate that adipocyte specific loss of Trim28 in committed adipocytes leads to sex specific differences in the development of obesity, and that this phenotype is associated with altered metabolic flexibility and lipid metabolism.

    • Simon T. Bond
    • Emily J. King
    • Brian G. Drew
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The integration of liver and plasma quantitative lipidomic and proteomic data from 107 distinct mouse strains provides important insights into regulators of mammalian lipid metabolism.

    • Benjamin L. Parker
    • Anna C. Calkin
    • Brian G. Drew
    Research
    Nature
    Volume: 567, P: 187-193

  • Bensinger and colleagues show that interferons promote host cell resistance to bacterial cytolysins by decreasing cholesterol synthesis and promoting the esterification of cholesterol, which alters the availability of this pool of ‘free’ cholesterol needed for pore formation.

    • Quan D. Zhou
    • Xun Chi
    • Steven J. Bensinger
    Research
    Nature Immunology
    Volume: 21, P: 746-755

  • Pulmonary alveolar proteinosis (PAP) is associated with defective macrophage clearance of surfactant. Here, the authors show that patients with PAP have altered cholesterol-to-phospholipid ratio in their surfactant, and that more importantly, statin therapy and reduction of cholesterol accumulation in macrophages can ameliorate PAP in both humans and mice.

    • Cormac McCarthy
    • Elinor Lee
    • Bruce C. Trapnell
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.

    • Julia J. Mack
    • Thiago S. Mosqueiro
    • M. Luisa Iruela-Arispe
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19