Nature Search

Cultural-ecosystem resilience is vital yet under-considered in coastal restoration

Jayur Madhusudan Mehta
Elizabeth L. Chamberlain
ResearchOpen Access29 May 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-12
Lowering the Mo limit for nitrogen fixation by Mo-nitrogenase

Substantial nitrogen fixation at sub-nanomolar molybdenum concentrations without alternative nitrogenases, with important implications for early Earth primary productivity, according to results from a ferruginous, low-sulfate, low-Mo, cyanobacteria-dominated lake.

Zackry Stevenson
Dylan L. Schultz
Elizabeth D. Swanner
ResearchOpen Access14 Jan 2026
Communications Earth & Environment

P: 1-8
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Somatic evolution following cancer treatment in normal tissue

High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

Oriol Pich
Sophia Ward
Nicholas McGranahan
ResearchOpen Access10 Dec 2025
Nature

P: 1-11
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Hydrolysis of Starch Grains by Polarized Infra-Red Radiation

ELIZABETH SIDNEY SEMMENS
Research05 Mar 1949
Nature

Volume: 163, P: 371
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Induced proximity-based therapeutic modalities

Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally modulate the target. This Review highlights seminal discoveries in the field, surveys the various modalities and discusses novel approaches to control cellular processes beyond protein degradation.

Elizabeth A. King
Margot Meyers
Daniel K. Nomura
Reviews31 Oct 2025
Nature Reviews Drug Discovery

P: 1-29
Influence of Continental Positions on Early Tertiary Climates

LAWRENCE A. FRAKES
ELIZABETH M. KEMP
Research10 Nov 1972
Nature

Volume: 240, P: 97-100
Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior

Striatal hyperactivity has been linked to compulsive behavior, but cell-type and pathway specific mechanisms are unclear. Here, the authors show excessive grooming in Sapap3-KO mice is associated with indirect pathway hyperactivity and suppression of hyperactivity normalizes grooming.

Sean C. Piantadosi
Elizabeth E. Manning
Susanne E. Ahmari
ResearchOpen Access24 May 2024
Nature Communications

Volume: 15, P: 1-17
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Lenalidomide, a derivative of thalidomide, is an effective drug for myelodysplastic syndrome; lenalidomide binds the CRL4^CRBN E3 ubiquitin ligase and promotes degradation of casein kinase 1a, on which the malignant cells rely for survival.

Jan Krönke
Emma C. Fink
Benjamin L. Ebert
Research01 Jul 2015
Nature

Volume: 523, P: 183-188
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial

The antisense oligonucleotide rugonersen has acceptable safety and tolerability in children with Angelman syndrome and shows partial normalization of electroencephalogram abnormalities and clinical improvements relative to natural history.

Jörg F. Hipp
Carlos A. Bacino
Federico Vigevano
Research11 Jul 2025
Nature Medicine

Volume: 31, P: 2936-2945
Large-scale migration into Britain during the Middle to Late Bronze Age

Genome-wide ancient DNA data from individuals from the Middle Bronze Age to Iron Age documents large-scale movement of people from the European continent between 1300 and 800 bc that was probably responsible for spreading early Celtic languages to Britain.

Nick Patterson
Michael Isakov
David Reich
Research22 Dec 2021
Nature

Volume: 601, P: 588-594
Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy

Annette K. Regan
Honorine Uwimana
Michelle L. Giles
ResearchOpen Access19 Apr 2025
npj Vaccines

Volume: 10, P: 1-17
Cascading hazards of a major Bengal basin earthquake and abrupt avulsion of the Ganges River

A major earthquake 2500 years ago caused one of the largest rivers on Earth to abruptly change its course. A recurrent event would pose the risk of such cascading hazards to the densely populated floodplains of present-day Bangladesh.

Elizabeth L. Chamberlain
Steven L. Goodbred
Christoph von Hagke
ResearchOpen Access17 Jun 2024
Nature Communications

Volume: 15, P: 1-12
Comparative effectiveness of alternative intervals between first and second doses of the mRNA COVID-19 vaccines

The optimal timing between first and second mRNA COVID-19 vaccine doses has not been established. Here, the authors use electronic health record data from Georgia, USA in a target trial emulation study to estimate vaccine effectiveness against infection for different dose intervals.

Kayoko Shioda
Alexander Breskin
Elizabeth T. Rogawski McQuade
ResearchOpen Access09 Feb 2024
Nature Communications

Volume: 15, P: 1-9
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer

The PSA (KLK3) genetic variant rs17632542 is associated with reduced prostate cancer risk and lower serum PSA levels, although the underlying reasons are unclear. Here, the authors show that this PSA variant reduced proteolytic activity and leads to smaller tumours, but also increases invasion and bone metastasis, indicating its dual risk association depending on tumour context; the variant is associated with both lower risk and poor clinical outcomes.

Srilakshmi Srinivasan
Thomas Kryza
Jyotsna Batra
ResearchOpen Access06 Nov 2024
Nature Communications

Volume: 15, P: 1-21
Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

Naomi A Fineberg
Marc N Potenza
Eric Hollander
Reviews25 Nov 2009
Neuropsychopharmacology

Volume: 35, P: 591-604
Sediment delivery to sustain the Ganges-Brahmaputra delta under climate change and anthropogenic impacts

The potential for enhanced sediment delivery to the Ganges-Brahmaputra delta exists, but it alone is insufficient to sustain the system. The delta may be resilient to climate change, but only in the absence of dam construction and water diversions.

Jessica L. Raff
Steven L. Goodbred Jr.
Lauren A. Williams
ResearchOpen Access27 Apr 2023
Nature Communications

Volume: 14, P: 1-13
The effects of lisdexamfetamine dimesylate on eating behaviour and homeostatic, reward and cognitive processes in women with binge-eating symptoms: an experimental medicine study

Elizabeth Schneider
Elizabeth Martin
Suzanne Higgs
ResearchOpen Access10 Jan 2022
Translational Psychiatry

Volume: 12, P: 1-8
CYP1B1-RMDN2 Alzheimer’s disease endophenotype locus identified for cerebral tau PET

A multi-cohort genome-wide association study of tau PET, a brain imaging-based marker of Alzheimer’s disease, identifies a CYP1B1-RMDN2 locus as associated with higher tau and faster cognitive decline. These results suggest a new genetic contribution to cerebral tau and target for Alzheimer’s disease research.

Kwangsik Nho
Shannon L. Risacher
Andrew J. Saykin
ResearchOpen Access20 Sept 2024
Nature Communications

Volume: 15, P: 1-14
A feasibility study of whole genome germline testing as an adjunct screening tool in a UK general private practice

Ann-Britt Jones
Gabriella Pichert
Michael Sandberg
ResearchOpen Access04 Nov 2025
Scientific Reports

Volume: 15, P: 1-12
High-Level Expression and In Vivo Processing of Chimeric Ubiquitin Fusion Proteins in Saccharomyces Cerevisiae

Elizabeth A. Sabin
Chun Ting Lee-Ng
Philip J. Barr
Research01 Jul 1989
Bio/Technology

Volume: 7, P: 705-709
Genome-wide association and expression quantitative trait loci in cattle reveals common genes regulating mammalian fertility

The authors identify the genetic variants and genes associated with four fertility-related traits in a well-phenotyped cattle population.

Mehrnush Forutan
Bailey N. Engle
Ben J. Hayes
ResearchOpen Access12 Jun 2024
Communications Biology

Volume: 7, P: 1-12
Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Christos Mikropoulos
Christina G Hutten Selkirk
Rosalind A Eeles
ResearchOpen Access04 Jan 2018
British Journal of Cancer

Volume: 118, P: 266-276
Treatment de-escalation for stage II seminoma

In this Perspective, current evidence to support de-escalation strategies of attenuated chemotherapy, radiotherapy and surgery for stage II seminoma to minimize the toxic effects of treatment is described and new potential de-escalation strategies are discussed.

Georgina E. Wood
Florence Chamberlain
Prabhakar Rajan
Reviews07 Mar 2023
Nature Reviews Urology

Volume: 20, P: 502-512
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Baby Open Brains: An open-source dataset of infant brain segmentations

Eric Feczko
Sally M. Stoyell
Jed T. Elison
ResearchOpen Access14 Aug 2025
Scientific Data

Volume: 12, P: 1-9
Zooplankton grazing is the largest source of uncertainty for marine carbon cycling in CMIP6 models

The rate of phytoplankton biomass loss to zooplankton grazing is the largest source of uncertainty across 11 CMIP6 model simulations of marine carbon cycling, which suggests that projected changes in ocean carbon export, and thus climate, are extremely sensitive to grazing pressure.

Tyler Rohr
Anthony J. Richardson
Elizabeth H. Shadwick
ResearchOpen Access14 Jun 2023
Communications Earth & Environment

Volume: 4, P: 1-22
Evolution of tissue and developmental specificity of transcription start sites in Bos taurus indicus

Forutan et al. measure RNA expression and map transcription start sites (TSSs) between two sub-species of cattle in adult and fetal tissues and demonstrate translocation and changes in TSS distribution between the sub-species. This study provides insight into cattle adaptation and provides support of rapidly evolving TSS between two recently diverged subspecies.

Mehrnush Forutan
Elizabeth Ross
Ben J. Hayes
ResearchOpen Access01 Jul 2021
Communications Biology

Volume: 4, P: 1-14
The Impact of Tryptophan Depletion and 5-HTTLPR Genotype on Passive Avoidance and Response Reversal Instrumental Learning Tasks

Elizabeth C Finger
Abigail A Marsh
James R Blair
Research09 Aug 2006
Neuropsychopharmacology

Volume: 32, P: 206-215
Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia

J. D. Griffin
K. M. J. Diederen
P. C. Fletcher
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-18
Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA repair genes

Sarah Benafif
Ann-Britt Jones
Ros Eeles
ResearchOpen Access15 Feb 2024
BJC Reports

Volume: 2, P: 1-6

Search

Cultural-ecosystem resilience is vital yet under-considered in coastal restoration

Lowering the Mo limit for nitrogen fixation by Mo-nitrogenase

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Mapping the human genetic architecture of COVID-19

Somatic evolution following cancer treatment in normal tissue

Whole-genome sequencing reveals host factors underlying critical COVID-19

Hydrolysis of Starch Grains by Polarized Infra-Red Radiation

Genetic mechanisms of critical illness in COVID-19

A second update on mapping the human genetic architecture of COVID-19

Induced proximity-based therapeutic modalities

Influence of Continental Positions on Early Tertiary Climates

Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial

Large-scale migration into Britain during the Middle to Late Bronze Age

Systematic review and meta-analysis of interventions to increase the uptake of vaccines recommended during pregnancy

Cascading hazards of a major Bengal basin earthquake and abrupt avulsion of the Ganges River

Comparative effectiveness of alternative intervals between first and second doses of the mRNA COVID-19 vaccines

A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

Sediment delivery to sustain the Ganges-Brahmaputra delta under climate change and anthropogenic impacts

The effects of lisdexamfetamine dimesylate on eating behaviour and homeostatic, reward and cognitive processes in women with binge-eating symptoms: an experimental medicine study

CYP1B1-RMDN2 Alzheimer’s disease endophenotype locus identified for cerebral tau PET

A feasibility study of whole genome germline testing as an adjunct screening tool in a UK general private practice

High-Level Expression and In Vivo Processing of Chimeric Ubiquitin Fusion Proteins in Saccharomyces Cerevisiae

Genome-wide association and expression quantitative trait loci in cattle reveals common genes regulating mammalian fertility

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Treatment de-escalation for stage II seminoma

Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Baby Open Brains: An open-source dataset of infant brain segmentations

Zooplankton grazing is the largest source of uncertainty for marine carbon cycling in CMIP6 models

Evolution of tissue and developmental specificity of transcription start sites in Bos taurus indicus

The Impact of Tryptophan Depletion and 5-HTTLPR Genotype on Passive Avoidance and Response Reversal Instrumental Learning Tasks

Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia

Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA repair genes

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