Glutaredoxin (GLRX) is a key enzyme in redox regulation via oxidation of protein cysteines and its activity is disrupted in diverse human diseases. This study integrates molecular modeling and biochemical validation to provide insights into the mechanisms of oxidative inactivation of GLRX.
- Elizabeth M. Corteselli
- Mona Sharafi
- Yvonne M. W. Janssen-Heininger
