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Advanced filters: Author: Elizabeth M. Rosethorne Clear advanced filters

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

Use of receptor variants in knock-in mice to dissect phosphorylation-dependent signaling from G protein-dependent signaling mediated by acetylcholine receptor M1 mAChR defines the ability of receptor ligands to modulate anxiety and locomotion behaviors.

Sophie J. Bradley
Colin Molloy
Andrew B. Tobin
Research20 Feb 2020
Nature Chemical Biology

Volume: 16, P: 240-249
Mechanisms that matter: unbiased cellular screening for degraders

Helen E. Burston
Elizabeth M. Rosethorne
Roland Hjerpe
ReviewsOpen Access17 Oct 2025
npj Drug Discovery

Volume: 2, P: 1-10

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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

Mechanisms that matter: unbiased cellular screening for degraders

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