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Showing 1–9 of 9 results
Advanced filters: Author: Elizabeth Montabana Clear advanced filters

  • Khan et al. show that Sec18 uses both D1 and D2 AAA+ rings cooperatively, opening them laterally for SNARE substrate loading and for subsequent release of SNAREs.

    • Yousuf A. Khan
    • K. Ian White
    • Axel T. Brunger
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1708-1720

  • A standardized, realistic phantom dataset consisting of ground-truth annotations for six diverse molecular species is provided as a community resource for cryo-electron-tomography algorithm benchmarking.

    • Ariana Peck
    • Yue Yu
    • Mohammadreza Paraan
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 1819-1823

  • We propose a model for a sequential, multistep activation mechanism of metabotropic glutamate receptor subtype 5, including a series of structures in lipid nanodiscs, from inactive to fully active, with agonist-bound intermediate states.

    • Kaavya Krishna Kumar
    • Haoqing Wang
    • Brian K. Kobilka
    Research
    Nature
    Volume: 629, P: 951-956

  • Initiation of HIV-1 reverse transcription occurs at the host tRNALys3, which forms a complex with the 5’ end of the HIV-1 viral RNA and reverse transcriptase (RT). Here, the authors present the 2.8 Å cryo-EM structure of a minimal HIV-1 RT–vRNA–tRNALys3 initiation complex (miniRTIC), and miniRTIC structures with the bound non-nucleoside reverse transcriptase inhibitors nevirapine and efavirenz at 3.1 and 2.9 Å resolution, respectively.

    • Betty Ha
    • Kevin P. Larsen
    • Elisabetta Viani Puglisi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Single-molecule spectroscopy and structural studies were used to examine the dynamics of association of eIF1A and eIF5B with the human translation initiation complex and their role in presenting tRNA to the complex to initiate translation.

    • Christopher P. Lapointe
    • Rosslyn Grosely
    • Joseph D. Puglisi
    Research
    Nature
    Volume: 607, P: 185-190