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Showing 1–2 of 2 results
Advanced filters: Author: Elizabeth Nenortas Clear advanced filters

  • Malaria parasites from patients who fail atovaquone therapies are highly drug-resistant, with mutations at Y268 in cytochrome b. Here the authors show that this mutation results in multiple defects in the parasite’s development and prevents transmission from mosquitoes to mice.

    • Victoria A. Balta
    • Deborah Stiffler
    • Theresa A. Shapiro
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • Long-acting antimalarials could provide improved prophylaxis and treatment options in the field. Here, Bakshi et al. develop a long-acting injectable atovaquone nanomedicine that prevents malaria infection prophylactically for up to 4 weeks in mice with no evidence for generation of resistant parasites.

    • Rahul P. Bakshi
    • Lee M. Tatham
    • Theresa A. Shapiro
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8