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Advanced filters: Author: Elizabeth Ottoni Clear advanced filters

  • Several rearrangements of the MLL gene are associated with acute leukemia, including the fusion of MLL with a RAS effector protein, AF6. Here the authors show that the truncated AF6 can induce AF6-MLL dimerization and drive its oncogenic activity.

    • Matthew J. Smith
    • Elizabeth Ottoni
    • Mitsuhiko Ikura
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13