Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–14 of 14 results
Advanced filters: Author: Elizabeth S. Sattely Clear advanced filters

  • Untargeted metabolomics and coexpression analysis uncovers the complete biosynthetic pathway of a previously unknown Arabidopsis metabolite, 4-hydroxyindole-3-carbonyl nitrile (4-OH-ICN), which harbours cyanogenic functionality.

    • Jakub Rajniak
    • Brenden Barco
    • Elizabeth S. Sattely
    Research
    Nature
    Volume: 525, P: 376-379

  • Paclitaxel is an important anticancer drug whose biosynthetic pathway reconstruction is hindered by the propensity of heterologously expressed pathway cytochromes P450, including taxadiene 5α-hydroxylase (T5αH), to form multiple products. Here, the authors tune the promoter strength for T5αH expression in Nicotiana plants to increase the levels of paclitaxel precursor taxadien-5α-ol by three-fold and reconstitute the six step early biosynthetic pathway of paclitaxel.

    • Jack Chun-Ting Liu
    • Ricardo De La Peña
    • Elizabeth S. Sattely
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose current production involves a laborious extraction process from yew trees.

    • Conor James McClune
    • Jack Chun-Ting Liu
    • Elizabeth S. Sattely
    ResearchOpen Access
    Nature
    Volume: 643, P: 582-592

  • Discovery of a near-complete colchicine biosynthetic pathway enables the engineered production of the tropolone-containing alkaloid N-formyldemecolcine from amino acid precursors in Nicotiana benthamiana.

    • Ryan S. Nett
    • Warren Lau
    • Elizabeth S. Sattely
    Research
    Nature
    Volume: 584, P: 148-153

  • Redirecting plant diterpene biosynthesis from the chloroplast to the cytosolic, high-flux mevalonate pathway increases intermediate and product titers to support the elucidation and reconstitution of momilactone biosynthesis.

    • Ricardo De La Peña
    • Elizabeth S. Sattely
    Research
    Nature Chemical Biology
    Volume: 17, P: 205-212

  • The identification and characterization of two cytochromes P450 from cabbage establish the biochemical basis for synthesizing brassinin-based phytoalexins, using two different routes of S-heterocyclization to construct these important vegetable compounds.

    • Andrew P Klein
    • Elizabeth S Sattely
    Research
    Nature Chemical Biology
    Volume: 11, P: 837-839

  • This paper discloses a new class of chiral catalysts that initiate olefin metathesis with exceptional efficiency and enantioselectivity. These new catalysts bear a stereogenic metal centre and carry only monodentate ligands; the molybdenum-based complexes are rendered non-racemic by a stereoselective ligand exchange process involving an enantiomerically pure aryloxide, a class of ligands rarely used in asymmetric catalysis.

    • Steven J. Malcolmson
    • Simon J. Meek
    • Amir H. Hoveyda
    Research
    Nature
    Volume: 456, P: 933-937

  • The biosynthesis and secretion of redox-active coumarins sideretin and fraxetin in Arabidopsis thaliana enables the plant to acquire iron under nutrient-limited conditions and provides a blueprint for the use of related compounds in other eudicots.

    • Jakub Rajniak
    • Ricardo F. H. Giehl
    • Elizabeth S. Sattely
    Research
    Nature Chemical Biology
    Volume: 14, P: 442-450

  • Germ-free mice were colonized with complex defined communities to show T cell recognition of commensals is focused on widely conserved, highly expressed cell-surface antigens, opening the door to new therapeutic strategies.

    • Kazuki Nagashima
    • Aishan Zhao
    • Michael A. Fischbach
    Research
    Nature
    Volume: 621, P: 162-170

  • Khlystov et al. introduce a new plant-based system (N. benthamiana) as a platform to rapidly produce a diverse array of recombinant fungal lignin-degrading enzymes. This study provides an initial framework to better understand the coordinated efforts of various lignin-degrading enzymes during fungal lignin deconstruction in nature.

    • Nikita A. Khlystov
    • Yasuo Yoshikuni
    • Elizabeth S. Sattely
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13