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Advanced filters: Author: Elke Neumann-Haefelin Clear advanced filters

Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient

Antibodies against SARS-CoV-2 can be used to treat infections but there is a risk of driving viral resistance to antibodies. Here the authors characterise SARS-CoV-2 escape mutants from an immunocompromised patient treated with anti-SARS-CoV-2 antibodies using mouse protection studies and structural prediction.

Lena Jaki
Sebastian Weigang
Jonas Fuchs
ResearchOpen Access10 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Saturation genome editing maps the functional spectrum of pathogenic VHL alleles

Saturation genome editing characterizes von Hippel–Lindau (VHL) coding variants and their associations with diseases. Function scores for 2,268 VHL single-nucleotide variants (SNVs) classify pathogenic alleles driving renal cell carcinoma and suggest new mechanisms by which variants impact function.

Megan Buckley
Chloé Terwagne
Gregory M. Findlay
ResearchOpen Access05 Jul 2024
Nature Genetics

Volume: 56, P: 1446-1455
VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma

Athina Ganner
Christina Gehrke
Elke Neumann-Haefelin
ResearchOpen Access21 Jul 2021
Scientific Reports

Volume: 11, P: 1-15

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