Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–19 of 19 results
Advanced filters: Author: Ellen V. Rothenberg Clear advanced filters

  • In this article, Ellen Rothenberg and colleagues review the key transcription factors and other regulatory factors involved in the processes of specification and commitment to the T-cell lineage, and outline the outstanding questions in the field.

    • Ellen V. Rothenberg
    • Jonathan E. Moore
    • Mary A. Yui
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 9-21

  • T cells of the immune system develop through a lineage-commitment step followed by two checkpoints. The finding that the first checkpoint is needed to complete commitment offers a fresh perspective on T-cell development.

    • Ellen V. Rothenberg
    News & Views
    Nature
    Volume: 613, P: 440-442

  • T cell development can be divided into three major regulatory phases by the checkpoints that occur at commitment to the T cell lineage and at β-selection. The three phases are each governed by different gene networks that confer distinct cellular characteristics. The correct developmental programme depends on the sequential operation of these gene networks, and cells that fail to enforce the boundaries between phases may be predisposed to leukaemic transformation.

    • Mary A. Yui
    • Ellen V. Rothenberg
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 529-545

  • Transcription factors of the Ets family are important for mammalian development. A genetic screen now finds that the Ets family member Erg is essential for definitive hematopoiesis and adult hematopoietic stem cell function.

    • Ellen V Rothenberg
    News & Views
    Nature Immunology
    Volume: 9, P: 714-716

  • TET proteins regulate 5-methylcytosine epigenetic marks, and thereby regulate chromatin accessibility. Rao and colleagues show that the combined loss of TET2 and TET3 in thymocytes skews development to iNKT17 cells as a result of upregulation of RORγt, which leads to lymphoproliferative disease and premature death.

    • Ageliki Tsagaratou
    • Edahí González-Avalos
    • Anjana Rao
    Research
    Nature Immunology
    Volume: 18, P: 45-53

  • Lineage specification and development require a hierarchy of transcription factors. A genome-wide view of transcription factor binding provides new insights into early B lineage development.

    • Ellen V Rothenberg
    News & Views
    Nature Immunology
    Volume: 11, P: 572-574

  • Targeting the transcription factor RORγt in autoimmunity could disrupt thymocyte development and lead to thymic lymphoma. Sun and colleagues identify a two-amino-acid substitution in RORγt that ‘preferentially’ disrupts TH17 differentiation, not thymocyte development.

    • Zhiheng He
    • Jian Ma
    • Zuoming Sun
    Research
    Nature Immunology
    Volume: 18, P: 1128-1138

  • Strong Notch signalling promotes initial T cell lineage specification of lymphoid progenitors but is also permissive for thymic natural killer (NK) cell development. Here the authors show that GATA3 directs human T-lineage commitment by modulating Notch activity and repressing the NK programme.

    • Inge Van de Walle
    • Anne-Catherine Dolens
    • Tom Taghon
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Given the right sequence of cues, embryonic stem cells can develop into any cell type found in the body. New work shows how manipulation of supportive stromal cells to provide essential Delta-Notch interactions allows embryonic stem cells to develop into functional T lymphocytes during in vitro culture.

    • Ellen V Rothenberg
    News & Views
    Nature Immunology
    Volume: 5, P: 359-360

  • Notch is heavily involved in T cell lineage commitment . . . or is it? New data indicates that neither CD4 nor CD8 cell maturation is Notch1-dependent, whereas Notch1 is critical for earlier steps in T cell development.

    • Ellen V. Rothenberg
    News & Views
    Nature Immunology
    Volume: 2, P: 189-190

  • A transcription factor network triggered by Notch signalling in the thymus guides proliferating, multipotent progenitor cells into the T cell pathway. This Review describes how these factors work to establish regulatory target specificity, epigenomic impact and irreversibility for T cell identity.

    • Hiroyuki Hosokawa
    • Ellen V. Rothenberg
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 162-176