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Showing 1–10 of 10 results
Advanced filters: Author: Ellen V. Stadler Clear advanced filters

  • Stadler et al. evaluate the diagnostic value of urinary tract infection biomarker, nitrite, in predicting disease progression and treatment efficacy. The longitudinal measurement of nitrite in an in-vitro UTI distinguishes between amoxicillin-resistant and susceptible E. coli strains and correlates with bacterial colony-forming unit counts in-vitro and in clinical UTI.

    • Ellen V. Stadler
    • Alison Holmes
    • Timothy M. Rawson
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-6

  • In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficient tumors is safe and elicits neoantigen-specific T cells in individuals with Lynch syndrome.

    • Anna Morena D’Alise
    • Jason Willis
    • Eduardo Vilar
    ResearchOpen Access
    Nature Medicine
    Volume: 32, P: 1002-1011

  • Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

    • Catherine M Phelan
    • Karoline B Kuchenbaecker
    • Paul D P Pharoah
    Research
    Nature Genetics
    Volume: 49, P: 680-691

  • Primary lymphomas of the central nervous system (PCNSL) are defined as diffuse large B-cell lymphomas (DLBCL) confined to the CNS. Here, the authors complete whole genome sequencing and RNA-seq to characterize 51 PCNSLs, and find common mutations in immune pathways and upregulated TERT expression and find distinct pathway differences between DLBCL and other primary CNS lymphomas.

    • Josefine Radke
    • Naveed Ishaque
    • Frank L. Heppner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that underpin this disease how alterations on different cellular levels cooperate in deregulating key pathways and complexes.

    • Cristina López
    • Kortine Kleinheinz
    • Reiner Siebert
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

    • Susanne N. Gröbner
    • Barbara C. Worst
    • Stefan M. Pfister
    ResearchOpen Access
    Nature
    Volume: 555, P: 321-327

  • Stadler et al. propose using existing technologies to link urinary biomarkers and antimicrobial drug levels for personalised treatment of urinary tract infections. This approach aims to enable real-time pharmacokinetic-pharmacodynamic monitoring and optimise individual antibiotic dosing.

    • Ellen V. Stadler
    • Alison Holmes
    • Timothy M. Rawson
    Comments & OpinionOpen Access
    Communications Medicine
    Volume: 5, P: 1-5