Nature Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

Chris Spencer, Eleanor Barnes and colleagues use human genotyping arrays and whole-genome viral sequencing to perform a systematic genome-to-genome study of 542 individuals chronically infected with hepatitis C virus (HCV). They show that both HLA alleles and genes encoding factors of the innate immune system drive viral genome polymorphism and that IFNL4 genotypes determine HCV viral load through a mechanism dependent on a specific polymorphism encoded in the HCV polyprotein.

M Azim Ansari
Vincent Pedergnana
Chris C A Spencer
Research10 Apr 2017
Nature Genetics

Volume: 49, P: 666-673
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Divergent trajectories of antiviral memory after SARS-CoV-2 infection

The engagement of immunological memory is a key component to the protective anti-SARS-CoV-2 B and T cell responses. Here the authors assess the B and T cells of a cohort of UK healthcare workers in response to infection and longitudinally track the compartment showing distinct trajectories following early priming.

Adriana Tomic
Donal T. Skelly
Susanna J. Dunachie
ResearchOpen Access10 Mar 2022
Nature Communications

Volume: 13, P: 1-20
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.

Julian C. Lui
Presley Garrison
Jeffrey Baron
ResearchOpen Access29 Nov 2016
Nature Communications

Volume: 7, P: 1-12
Infection of liver hepatocytes with SARS-CoV-2

Multi-organ disease in patients seriously unwell with COVID-19 is commonly reported. However, debate exists as to whether extra-pulmonary manifestations are the result of indirect effects or of direct extra-pulmonary organ infection. Wanner et al. attempt to tackle this issue with a focus on liver tropism of the SARS-CoV-2 virus.

Eleanor Barnes
News & Views28 Mar 2022
Nature Metabolism

Volume: 4, P: 301-302
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
ResearchOpen Access21 Feb 2020
Nature Communications

Volume: 11, P: 1-15
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

The adhesion receptor CD2 plays an important role in the full activation of T cells. Dustin and colleagues show that CD2 occupies a region in the periphery of the immunological synapse where it amplifies cognate antigen signals, whereas the presence of PD-1 disrupts this effect.

Philippos Demetriou
Enas Abu-Shah
Michael L. Dustin
Research14 Sept 2020
Nature Immunology

Volume: 21, P: 1232-1243
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

The cytokine oncostatin M drives intestinal inflammation in mice, and its abundance in the intestine of patients with inflammatory bowel disease predicts response to tumor necrosis factor–neutralizing therapy.

Nathaniel R West
Ahmed N Hegazy
Fiona Powrie
Research03 Apr 2017
Nature Medicine

Volume: 23, P: 579-589
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Copy number variants (CNVs) account for a major proportion of human genetic diversity and may contribute to genetic susceptibility to disease. Here, a large, genome-wide study of association between common CNVs and eight common human diseases is presented. The study provides a wealth of technical insights that will inform future study design and analysis. The results also indicate that common CNVs that can be 'typed' on existing platforms are unlikely to contribute much to the genetic basis of common diseases.

Nick Craddock
Matthew E. Hurles
Peter Donnelly
Research01 Apr 2010
Nature

Volume: 464, P: 713-720
Author Correction: A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

Philippos Demetriou
Enas Abu-Shah
Michael L. Dustin
Amendments and Corrections29 Oct 2020
Nature Immunology

Volume: 22, P: 99
COVID-19 and liver disease: mechanistic and clinical perspectives

This Review provides mechanistic and clinical insights into COVID-19 in the context of liver disease, discussing the potential underlying biology and clinical features of SARS-CoV-2 infection in patients with pre-existing liver conditions. The management of these patients is also discussed, including SARS-CoV-2 vaccination strategies.

Thomas Marjot
Gwilym J. Webb
Eleanor Barnes
Reviews10 Mar 2021
Nature Reviews Gastroenterology & Hepatology

Volume: 18, P: 348-364
The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation

Michael Chau
Zelong Dou
Ola Nilsson
ResearchOpen Access16 Sept 2022
npj Regenerative Medicine

Volume: 7, P: 1-17
The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses

This Review discusses the evidence for pre-existing cross-reactive immune responses to SARS-CoV-2, which are mainly due to infections with common cold coronaviruses, and how such cross-reactivity affects adaptive immune responses. Furthermore, it explores cross-reactivity in the context of SARS-CoV-2 variants of concern and its implications for vaccine development.

Sam M. Murray
Azim M. Ansari
Ane Ogbe
Reviews20 Dec 2022
Nature Reviews Immunology

Volume: 23, P: 304-316
Evidence of CD4⁺ T cell-mediated immune pressure on the Hepatitis C virus genome

Michaela Lucas
Pooja Deshpande
Silvana Gaudieri
ResearchOpen Access08 May 2018
Scientific Reports

Volume: 8, P: 1-10
Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Eva Gonçalves Serra
Tobias Schwerd
Carl A. Anderson
Amendments and CorrectionsOpen Access22 Jun 2022
Nature Communications

Volume: 13, P: 1
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto Romagnoni
Simon Jégou
Pamela Whittaker
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-18
NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

T Schwerd
R V Bryant
H H Uhlig
ResearchOpen Access01 Nov 2017
Mucosal Immunology

Volume: 11, P: 562-574

Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Mapping the human genetic architecture of COVID-19

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

Whole-genome sequencing reveals host factors underlying critical COVID-19

A second update on mapping the human genetic architecture of COVID-19

Divergent trajectories of antiviral memory after SARS-CoV-2 infection

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

Infection of liver hepatocytes with SARS-CoV-2

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Author Correction: A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

COVID-19 and liver disease: mechanistic and clinical perspectives

The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation

The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses

Evidence of CD4⁺ T cell-mediated immune pressure on the Hepatitis C virus genome

Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

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