Nature Search

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

The expression of oncogenic MYC paralogs in small cell lung cancer is mutually exclusive. In this study, the authors show that MYC, but not MYCN or MYCL, represses BCL2, resulting in cells that are uniquely sensitive to apoptosis, and find that CHK1 and AURKA inhibitors may be useful for treating these cancers.

Marcel A. Dammert
Johannes Brägelmann
Martin L. Sos
ResearchOpen Access02 Aug 2019
Nature Communications

Volume: 10, P: 1-11
Complete coverage of the Schizosaccharomyces pombe genome in yeast artificial chromosomes

Elmar Maier
Jörg D. Hoheisel
Hans Lehrach
Research01 Jul 1992
Nature Genetics

Volume: 1, P: 273-277
Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis

Karthika Rajeeve
Nadine Vollmuth
Thomas Rudel
Amendments and Corrections15 Feb 2021
Nature Microbiology

Volume: 6, P: 533
Miz1 is required to maintain autophagic flux

Miz1 is a binding partner of the transcription factor c-Myc and a regulator of cell cycle progression. Wolf et al. show that inactivation of Miz1 in the mouse central nervous system results in neurodegeneration, and find that Miz1 is essential for the transcriptional regulation of autophagic flux.

Elmar Wolf
Anneli Gebhardt
Martin Eilers
Research03 Oct 2013
Nature Communications

Volume: 4, P: 1-12
A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment

Reproduction in numerous marine organisms is timed to specific moon phases, but the mechanisms for sensing moon phases are incompletely understood. Here the authors report that an ancient, light-sensitive protein L-Cryptochrome in a marine bristle worm can discriminate between sun- and moonlight, enabling the animals to properly decode moon phases.

Birgit Poehn
Shruthi Krishnan
Kristin Tessmar-Raible
ResearchOpen Access05 Sept 2022
Nature Communications

Volume: 13, P: 1-18
A marine cryptochrome with an inverse photo-oligomerization mechanism

Cryptochromes are important components of biological clocks. Here, the authors uncover that a cryptochrome that enables synchronization of the reproduction of marine worms to the lunar cycle uses an inverse photo-oligomerization mechanism.

Hong Ha Vu
Heide Behrmann
Elmar Behrmann
ResearchOpen Access30 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Correction: Corrigendum: Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Susanne Walz
Francesca Lorenzin
Martin Eilers
Amendments and Corrections17 Dec 2014
Nature

Volume: 516, P: 440
A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

Schmidt et al. show that the translation initiation factor eIF2B5 regulates stress responses and MYC translation to prevent apoptosis, thereby presenting a targetable vulnerability in colorectal cancer.

Stefanie Schmidt
David Gay
Armin Wiegering
Research04 Nov 2019
Nature Cell Biology

Volume: 21, P: 1413-1424
Psychometric properties and norm values of a short screening version of the profile of mood states POMS from the German general population

Katja Petrowski
Monika Bjelopavlovic
Bjarne Schmalbach
ResearchOpen Access04 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
MYC multimers shield stalled replication forks from RNA polymerase

MYC dissociation from active promoters alters its interactions with proteins involved in transcription termination and RNA processing, influencing DNA repair and thus, potentially, tumour cell growth.

Daniel Solvie
Apoorva Baluapuri
Martin Eilers
Research23 Nov 2022
Nature

Volume: 612, P: 148-155
Induced proximity to PML protects TDP-43 from aggregation via SUMO–ubiquitin networks

TDP-43 aggregates are a hallmark of neurodegeneration. Wagner et al. show that SUMOylation/ubiquitylation of TDP-43, mediated by its recruitment to the promyelocytic leukemia protein nuclear bodies, prevents its aggregation under proteotoxic stresses.

Kristina Wagner
Jan Keiten-Schmitz
Stefan Müller
ResearchOpen Access17 Apr 2025
Nature Chemical Biology

Volume: 21, P: 1408-1419
The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes

Herpes simplex virus 1 (HSV-1) infection disrupts transcription termination by RNA Polymerase II. Here, Djakovic et al. identify the immediate-early protein ICP22 protein of HSV-1 to induce open chromatin downstream of genes upon read-through transcription involving the histone chaperone FACT.

Lara Djakovic
Thomas Hennig
Lars Dölken
ResearchOpen Access31 Jul 2023
Nature Communications

Volume: 14, P: 1-17
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

A bifunctional AURORA-A degrader induces the fast and specific degradation of this kinase in cancer cell lines, which enables targeting of non-catalytic, oncogenic functions of AURORA-A resulting in S-phase arrest and rampant apoptosis.

Bikash Adhikari
Jelena Bozilovic
Elmar Wolf
Research28 Sept 2020
Nature Chemical Biology

Volume: 16, P: 1179-1188
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation

Snaebjornsson et al. explore a selective vulnerability in cancer elicited by targeting aldolase A, which causes energy imbalance and prevents further metabolic adaptations.

Marteinn T. Snaebjornsson
Philipp Poeller
Almut Schulze
ResearchOpen Access20 Jan 2025
Nature Metabolism

Volume: 7, P: 348-366
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Inducing changes in the levels of the MYC oncoprotein is shown to activate and repress specific sets of target genes that are characteristic of tumour cells, providing an insight into the mechanism by which MYC can stimulate tumorigenesis in contrast to its physiological role.

Susanne Walz
Francesca Lorenzin
Martin Eilers
Research09 Jul 2014
Nature

Volume: 511, P: 483-487
GraFix: sample preparation for single-particle electron cryomicroscopy

Berthold Kastner
Niels Fischer
Holger Stark
Research23 Dec 2007
Nature Methods

Volume: 5, P: 53-55
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma

SUMOylation is a post-translational modification that has been shown to be altered in cancer. Here, the authors show that loss of the SUMO isopeptidase SENP6 leads to unrestricted SUMOylation and genomic instability promoting lymphomagenesis and generating vulnerability to PARP inhibition.

Markus Schick
Le Zhang
Ulrich Keller
ResearchOpen Access12 Jan 2022
Nature Communications

Volume: 13, P: 1-16
Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis

This study describes the mechanism by which Chlamydia trachomatis reprogrammes host glutamine metabolism in a c-Myc-dependent manner. The authors show that glutamine uptake via the SLC15A transporter and glutaminolysis are crucial for peptidoglycan synthesis and Chlamydia replication.

Karthika Rajeeve
Nadine Vollmuth
Thomas Rudel
Research03 Aug 2020
Nature Microbiology

Volume: 5, P: 1390-1402
MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by competing with the Mit/TFE transcription factors for occupancy of their target gene promoters.

Ida Annunziata
Diantha van de Vlekkert
Alessandra d’Azzo
ResearchOpen Access09 Aug 2019
Nature Communications

Volume: 10, P: 1-18
Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

The tri-snRNP is the largest preassembled unit of the spliceosome, and its components are key to the splicing reaction. The overall structure and conformations of the yeast tri-snRNP are now analyzed by EM, and the general positions of some of its major protein components mapped.

Irina Häcker
Bjoern Sander
Reinhard Lührmann
Research26 Oct 2008
Nature Structural & Molecular Biology

Volume: 15, P: 1206-1212
The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells

The longevity of hematopoietic stem cells requires strict regulation to prevent their exhaustion. Aifantis and colleagues show that the ubiquitin E3 ligase Huwe1 is needed to suppress the activity of the transcription factor N-myc and maintain the quiescence and function of these cells.

Bryan King
Francesco Boccalatte
Iannis Aifantis
Research26 Sept 2016
Nature Immunology

Volume: 17, P: 1312-1321
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase

In human neuroblastoma tumours, MYCN is engaged in a USP11–BRCA1-dependent manner to suppress the accumulation of stalled RNAPII and induces both the activation and repression of genes.

Steffi Herold
Jacqueline Kalb
Martin Eilers
Research20 Mar 2019
Nature

Volume: 567, P: 545-549
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Michaela Reissland
Oliver Hartmann
Markus E. Diefenbacher
ResearchOpen Access23 Oct 2024
Oncogene

Volume: 43, P: 3645-3659
Target gene-independent functions of MYC oncoproteins

The MYC oncoproteins are transcription factors, but the molecular mechanism of their oncogenic activity is unclear. MYC proteins promote transcription termination in stress conditions, which is proposed to increase cellular resilience to stress and to promote tumorigenesis independently of changes in the expression of their target genes.

Apoorva Baluapuri
Elmar Wolf
Martin Eilers
Reviews18 Feb 2020
Nature Reviews Molecular Cell Biology

Volume: 21, P: 255-267
Correction: The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression

Christina Jessen
Julia K. C. Kreß
Svenja Meierjohann
Amendments and Corrections01 Dec 2020
Oncogene

Volume: 40, P: 1391
The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression

Christina Jessen
Julia K. C. Kreß
Svenja Meierjohann
ResearchOpen Access25 Sept 2020
Oncogene

Volume: 39, P: 6841-6855
Correction: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Michaela Reissland
Oliver Hartmann
Markus E. Diefenbacher
Amendments and CorrectionsOpen Access22 Jan 2025
Oncogene

Volume: 44, P: 336

Search

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

Complete coverage of the Schizosaccharomyces pombe genome in yeast artificial chromosomes

Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis

Miz1 is required to maintain autophagic flux

A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment

A marine cryptochrome with an inverse photo-oligomerization mechanism

Correction: Corrigendum: Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

Psychometric properties and norm values of a short screening version of the profile of mood states POMS from the German general population

MYC multimers shield stalled replication forks from RNA polymerase

Induced proximity to PML protects TDP-43 from aggregation via SUMO–ubiquitin networks

The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase

Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

GraFix: sample preparation for single-particle electron cryomicroscopy

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma

Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis

MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells

Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Target gene-independent functions of MYC oncoproteins

Correction: The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression

The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression

Correction: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

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