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Showing 1–23 of 23 results
Advanced filters: Author: Elodie Ghedin Clear advanced filters
  • A group of microbiome researchers discuss some of the challenges in developing a new generation of microbiome therapies.

    • Gaspar Taroncher-Oldenburg
    • Susan Jones
    • Jun Wang
    Special Features
    Nature Biotechnology
    Volume: 36, P: 1037-1042
  • Elodie Ghedin, Benjamin Cowling and colleagues quantify the frequency at which variants of influenza virus were transmitted between individual hosts during the 2009 H1N1 pandemic in Hong Kong. They find transmission of multiple variants between donor-recipient pairs and provide estimates of the number of viral particles that can infect and replicate within a host.

    • Leo L M Poon
    • Timothy Song
    • Elodie Ghedin
    Research
    Nature Genetics
    Volume: 48, P: 195-200
  • Here, the authors isolate a SARS-CoV-2 mutant that has developed decreased sensitivity to Paxlovid and remdesivir from an immunocompromised patient, show that drug resistance can be overcome by simultaneous treatment with both drugs in vitro, and demonstrate that the drug resistant virus can efficiently transmit in the hamster model.

    • Mohammed Nooruzzaman
    • Katherine E. E. Johnson
    • Mirella Salvatore
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Many nematode worms, including Caenorhabditis elegans have XX/XO sex determination, while other species have XY. The authors use a new genome assembly of the filarial parasite Brugia malayi and published data to show that nematode sex chromosome evolution is highly plastic.

    • Jeremy M. Foster
    • Alexandra Grote
    • Elodie Ghedin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • It is unclear why pregnant women are at high risk of severe influenza infection. Allogeneic pregnancy in mice is now shown to alter both innate and adaptive responses to influenza virus infection, enabling the emergence of more virulent virus variants.

    • Elodie Ghedin
    • Stacey Schultz-Cherry
    News & Views
    Nature Microbiology
    Volume: 2, P: 1-2
  • Two new studies report genomic data on three species of whipworm, soil-transmitted parasitic worms responsible for trichuriasis. These genomes provide insights into host-pathogen interactions and potential for new drug targets for helminth therapy.

    • Elodie Ghedin
    News & Views
    Nature Genetics
    Volume: 46, P: 661-663
  • Sequencing data reveal highly diverse viromes associated with clinically important parasitic nematodes. Serological data suggest that this ongoing relationship could impact disease.

    • Elodie Ghedin
    • Megan R. Hockman
    News & Views
    Nature Microbiology
    Volume: 9, P: 2473-2474
  • Lung samples housed in medical archives have yielded three genomes for the influenza A virus that caused the 1918 global pandemic. The sequences reveal mutations that might have triggered the pandemic’s devastating second wave.

    • Martha I. Nelson
    • Elodie Ghedin
    News & Views
    Nature
    Volume: 607, P: 244-245
  • Characterization of the genomes of the parasite Onchocerca volvulus, the causative agent of river blindness, and its Wolbachia symbiont reveals potential therapeutic targets.

    • James A. Cotton
    • Sasisekhar Bennuru
    • Sara Lustigman
    ResearchOpen Access
    Nature Microbiology
    Volume: 2, P: 1-12
  • The World Health Organization framework for tracking SARS-CoV-2 variants has been updated to reflect the continued evolution of the virus; this framework could be adapted for other emerging respiratory diseases with epidemic and pandemic potential.

    • Lorenzo Subissi
    • James Richard Otieno
    • Maria D. Van Kerkhove
    Comments & Opinion
    Nature Medicine
    Volume: 30, P: 2400-2403
  • Here, the authors describe the global distribution of crAssphage, its presence in Old-World and New-World primates, and its association with gut bacterial communities and dietary factors, providing insights into the origin, evolution and epidemiology of human gut crAssphage.

    • Robert A. Edwards
    • Alejandro A. Vega
    • Bas E. Dutilh
    Research
    Nature Microbiology
    Volume: 4, P: 1727-1736
  • The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

    • Marciela M. DeGrace
    • Elodie Ghedin
    • Mehul S. Suthar
    Reviews
    Nature
    Volume: 605, P: 640-652
  • Global sequencing and surveillance capacity for SARS-CoV-2 must be strengthened and combined with multidisciplinary studies of infectivity, virulence and immune escape, in order to track the unpredictable evolution of the ongoing COVID-19 pandemic.

    • Lorenzo Subissi
    • Anne von Gottberg
    • Anurag Agrawal
    Comments & Opinion
    Nature Medicine
    Volume: 28, P: 1110-1115
  • Understanding the factors that enable some bird flu viruses to infect humans is important for the identification of circulating viruses with higher potential to infect us. Here, Taft et al.identify novel mutations in the polymerase of an avian H5N1 virus that help the virus to replicate in human cells and in mice

    • Andrew S. Taft
    • Makoto Ozawa
    • Yoshihiro Kawaoka
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12
  • Schistosoma mansoni and Schistosoma japonicum are the pathogenic agents that cause the tropical disease schistosomiasis. Here, and in an accompanying paper, the genomes of these two flatworms are sequenced and analysed. The results provide insights into the molecular architecture and host interactions of the flatworms, as well as avenues for future development of targeted interventions for schistosomiasis.

    • Matthew Berriman
    • Brian J. Haas
    • Najib M. El-Sayed
    ResearchOpen Access
    Nature
    Volume: 460, P: 352-358
  • The availability of high-yield virus strains remains an important bottleneck in the rapid production of influenza vaccines. Here, the authors report the development of influenza A vaccine backbone that improves the virus yield of various seasonal and pandemic influenza vaccine strains in cell culture.

    • Jihui Ping
    • Tiago J.S. Lopes
    • Yoshihiro Kawaoka
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15