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Investigation of Ribonuclease Isozymes by an Electrophoretic Ultra-Violet Method

NEWTON RESSLER
EDWIN OLIVERO
RAMON R. JOSEPH
Research14 May 1966
Nature

Volume: 210, P: 695-698
Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila

Neural mechanisms underlying state-dependent flexible selection are not fully understood. Here authors show that NPY homologues in Drosophila larva differentially modulate reciprocally connected inhibitory neurons to bias non-feeding decisions, favoring escape-type actions (Head Cast), over protective-type actions (Hunch), in response to a mechanical cue.

Eloïse de Tredern
Dylan Manceau
Tihana Jovanic
ResearchOpen Access02 Sept 2025
Nature Communications

Volume: 16, P: 1-24
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′ splice-site use is shown to be systematically disrupted in individuals with RNU4-2 variants.

Yuyang Chen
Ruebena Dawes
Nicola Whiffin
ResearchOpen Access11 Jul 2024
Nature

Volume: 632, P: 832-840
Whole-genome sequencing of 490,640 UK Biobank participants

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Keren Carss
Bjarni V. Halldorsson
Ole Schulz-Trieglaff
ResearchOpen Access06 Aug 2025
Nature

Volume: 645, P: 692-701
Central nervous system-associated macrophages modulate the immune response following stroke in aged mice

How aging influences peripheral immune cell infiltration and the role of these cells following traumatic injury of the CNS is unclear. Here, the authors show that aging transforms CNS-associated macrophages into regulators of immune cell trafficking after ischemic stroke, modulating neurological outcomes.

Damien Levard
Célia Seillier
Marina Rubio
Research03 Jul 2024
Nature Neuroscience

Volume: 27, P: 1721-1733
Wireless electrical–molecular quantum signalling for cancer cell apoptosis

Quantum biological electron transfer has potential in diagnostic and therapeutic settings. Here the authors report the triggered apoptosis of cancer cells using electricical input to wirelessly induce redox interactions at bio-nanoantennae in proximity to cancer cells.

Akhil Jain
Jonathan Gosling
Frankie J. Rawson
ResearchOpen Access14 Sept 2023
Nature Nanotechnology

Volume: 19, P: 106-114
An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63

Double-strand breaks in DNA activate the kinases ATM and ATR, which block entry into mitosis. ATM and ATR also delay mitotic progression by controlling spindle assembly in Xenopus egg extracts through the phosphorylation of the centrosomal protein CEP63, leading to its delocalization from the centrosome.

Eloise Smith
Donniphat Dejsuphong
Vincenzo Costanzo
Research01 Feb 2009
Nature Cell Biology

Volume: 11, P: 278-285
Diverse monogenic subforms of human spermatogenic failure

The GEMINI consortium sequenced 1,000 cases of idiopathic male infertility and identified a plausible Mendelian cause in 20% of cases. The infertility genes can be grouped by expression pattern, facilitating their interpretation and follow-up.

Liina Nagirnaja
Alexandra M. Lopes
Donald F. Conrad
ResearchOpen Access26 Dec 2022
Nature Communications

Volume: 13, P: 1-18
Author Correction: Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
Amendments and CorrectionsOpen Access13 May 2026
npj Digital Medicine

Volume: 9, P: 1
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.

Eleanor Barnes
Carl S. Goodyear
Deborah Richardson
ResearchOpen Access06 Jul 2023
Nature Medicine

Volume: 29, P: 1760-1774
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

In this Resource, Buckley and colleagues profile patients with Crohn’s disease and ulcerative colitis before and after adalimumab therapy. Specific pretreatment differences in the epithelial and myeloid compartments were associated with remission outcomes in both diseases. The authors also describe the cellular circuitry in nonremission patients following treatment.

Tom Thomas
Matthias Friedrich
Christopher D. Buckley
ResearchOpen Access22 Oct 2024
Nature Immunology

Volume: 25, P: 2152-2165
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Overgrowth syndromes — clinical and molecular aspects and tumour risk

Overgrowth syndromes are a heterogeneous group of rare disorders characterized by generalized or segmental excessive growth. This Review discusses the clinical and molecular diagnosis, tumour risk and recommendations for tumour screening for the most prevalent generalized and segmental overgrowth syndromes.

Frédéric Brioude
Annick Toutain
Irene Netchine
Reviews06 Mar 2019
Nature Reviews Endocrinology

Volume: 15, P: 299-311
Circumtropical distribution and cryptic species of the meiofaunal enteropneust Meioglossus (Harrimaniidae, Hemichordata)

Éloïse Defourneaux
Maria Herranz
Katrine Worsaae
ResearchOpen Access23 Apr 2024
Scientific Reports

Volume: 14, P: 1-20
Immunology of age-related macular degeneration

Immune dysfunction is a recurring theme in the pathogenesis of age-related macular degeneration, which is the leading cause of blindness in aged individuals. Understanding the dual nature of ocular immune pathways in both visual homeostasis and retinal damage could aid the development of immune-based therapeutics for this disease.

Jayakrishna Ambati
John P. Atkinson
Bradley D. Gelfand
Reviews24 May 2013
Nature Reviews Immunology

Volume: 13, P: 438-451
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12

Search

Investigation of Ribonuclease Isozymes by an Electrophoretic Ultra-Violet Method

Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila

SARS-CoV-2 evolution during treatment of chronic infection

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Genomic reconstruction of the SARS-CoV-2 epidemic in England

De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

Whole-genome sequencing of 490,640 UK Biobank participants

Central nervous system-associated macrophages modulate the immune response following stroke in aged mice

Wireless electrical–molecular quantum signalling for cancer cell apoptosis

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63

Diverse monogenic subforms of human spermatogenic failure

Author Correction: Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Overgrowth syndromes — clinical and molecular aspects and tumour risk

Circumtropical distribution and cryptic species of the meiofaunal enteropneust Meioglossus (Harrimaniidae, Hemichordata)

Immunology of age-related macular degeneration

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

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