Tup1 was identified as a transcriptional repressor; however the protein remains associated with promoters of target genes after activation. Ng et al. show that Tup1 is SUMOylated under stress conditions, and that SUMOylation is required for persistence of Tup1 at active promoters.
- Chong Han Ng
- Akhi Akhter
- James L. Manley
