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Showing 1–6 of 6 results
Advanced filters: Author: Emanuela Zuccaro Clear advanced filters

  • Although myelination largely occurs during early postnatal life, myelinating oligodendrocytes are still generated in the adult brain. Myelin turnover in the adult is necessary for proper neuronal function and is gravely compromised in myelin disorders. The lineage relationship between adult neural stem cells and adult-born oligodendrocytes has been clarified, highlighting molecular pathways that could potentially be targeted to favour de novo myelination in pathological situations.

    • Emanuela Zuccaro
    • Paola Arlotta
    News & Views
    Nature Cell Biology
    Volume: 15, P: 572-575

  • Marchioretti and colleagues show that in the skeletal muscle of SBMA mice and patients there is an early, but reversible alteration of expression of genes involved in muscle contraction and of mitochondrial respiration, followed by accumulation of calcium inside the mitochondria, which is concomitant with the onset of motor dysfunction, and late alteration of muscle structure.

    • Caterina Marchioretti
    • Giulia Zanetti
    • Maria Pennuto
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • How the 22q11.2 deletion predisposes to psychiatric disease is unclear. Here, the authors examine living human neuronal cells and show that 22q11.2 regulates the expression of genes linked to autism during early development, and genes linked to schizophrenia and synaptic biology in neurons.

    • Ralda Nehme
    • Olli Pietiläinen
    • Kevin Eggan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Here, Prakasam and colleagues show that polyQ-expanded androgen receptor toxicity can be attenuated using artificial miRNAs targeting Lsd1 and Prmt6, two AR-co-activators overexpressed in an androgen-dependent manner specifically in skeletal muscle, thus ameliorating spinal-bulbar muscular atrophy phenotypes in flies and mice.

    • Ramachandran Prakasam
    • Angela Bonadiman
    • Maria Pennuto
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • The exact molecular mechanisms driving FUS-mediated toxicity remain unclear. Here, the authors demonstrate that muscleblind (Mbl) is a novel modifier of FUS-associated ALS, with knockdown of endogenous Mbl suppressing neuromuscular junction defects and motor dysfunctions associated with FUS expression in Drosophila, as well as restoring reduced SMN protein levels in mammalian neuronal and human iPSC-derived motor neurons.

    • Ian Casci
    • Karthik Krishnamurthy
    • Udai Bhan Pandey
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-20

  • Fezf2 (Fezl) is a transcription factor that specifies corticospinal motor neurons (CSMN) originating from cortical layer 5b. Lodato et al. use cortical progenitor isolation from developing mouse brain and gene expression profiling to identify genes downstream of Fezf2 and demonstrate co-regulation of CSMN gene ensembles by Fezf2 in establishing CSMN cell identity.

    • Simona Lodato
    • Bradley J Molyneaux
    • Paola Arlotta
    Research
    Nature Neuroscience
    Volume: 17, P: 1046-1054