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Showing 1–10 of 10 results
Advanced filters: Author: Emil L. Sigurdsson Clear advanced filters

  • Understanding the underlying pathophysiology of obesity can help prevent this condition. Here, the authors perform a GWAS of BMI in diverse ancestries, finding four missense variants in FRS3 that affect BMI.

    • Andrea B. Jonsdottir
    • Gardar Sveinbjornsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Genome-wide association analyses using parental and offspring genotypes provide insights into fetal and maternal genetic effects on fetal growth. The results show that maternal and fetal genomes influence birth weight through distinct mechanisms.

    • Thorhildur Juliusdottir
    • Valgerdur Steinthorsdottir
    • Kari Stefansson
    Research
    Nature Genetics
    Volume: 53, P: 1135-1142

  • Meta-analyses in up to 1.3 million individuals identify 87 rare-variant associations with blood pressure traits. On average, rare variants exhibit effects ~8 times larger than the mean effects of common variants and implicate candidate causal genes at associated regions.

    • Praveen Surendran
    • Elena V. Feofanova
    • Joanna M. M. Howson
    Research
    Nature Genetics
    Volume: 52, P: 1314-1332

  • Holm, Ivarsdottir, Olafsdottir et al. compare symptoms and physical measures between Icelanders post SARS-CoV-2 infection with uninfected controls. From reported symptoms, they estimate the prevalence of long COVID as 7% at a median of 8 months after infection, while objective differences between cases and controls in the physical measures were few.

    • Hilma Holm
    • Erna V. Ivarsdottir
    • Kari Stefansson
    ResearchOpen Access
    Communications Medicine
    Volume: 3, P: 1-13

  • The concentration of SARS-CoV-2 changes during an individual’s infection, and mutations accumulate as viruses are transmitted between people. Here, the authors use data from Iceland to demonstrate how this information can be exploited at the population-level to determine the phase of the epidemic.

    • Hakon Jonsson
    • Olafur T. Magnusson
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Aberrant morphology of the QRS complex in an electrocardiogram can be associated with cardiac morbidity and mortality. Here, the authors perform genome-wide association studies for ten measures of the QRS complex in 81,192 individuals and find 86 previously unreported loci that associate with at least one parameter.

    • Kristjan Norland
    • Gardar Sveinbjornsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Genome-wide analyses identify loci associated with nonalcoholic fatty liver disease, including rare, protective loss-of-function variants in MTARC1 and GPAM. Plasma proteomic analyses provide insight into proteins involved in disease pathogenesis.

    • Gardar Sveinbjornsson
    • Magnus O. Ulfarsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1652-1663

  • Aortic valve stenosis (AS) is the most common valvular heart disease. Here the authors identify two new AS loci that also associate with bicuspid aortic valve, aortic root diameter and/or coronary artery disease implicating both developmental abnormalities and atherosclerosis-like processes in AS.

    • Anna Helgadottir
    • Gudmar Thorleifsson
    • Kari Stefansson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Evgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hypertension, as well as a genetic overlap between platelet count and various physiological markers.

    • Evgenia Mikaelsdottir
    • Gudmar Thorleifsson
    • Kari Stefansson
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13