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Showing 1–3 of 3 results
Advanced filters: Author: Emiliano Marasco Clear advanced filters

  • Peter Gregersen and colleagues identify a regulatory variant in CSK, coding for an intracellular kinase that physically interacts with Lyp (PTPN22), associated with systemic lupus erythematosus (SLE). Their work suggests that the Lyp-Csk complex influences susceptibility to SLE through regulation of B-cell signaling, maturation and activation.

    • Nataly Manjarrez-Orduño
    • Emiliano Marasco
    • Peter K Gregersen
    Research
    Nature Genetics
    Volume: 44, P: 1227-1230

  • Interferon-γ (IFNγ) is important in innate and adaptive immunity and its overproduction is also implicated in hyperinflammation. Here, De Benedetti and colleagues discuss the evidence for a pathogenetic role of IFNγ in hyperinflammatory diseases, the search for IFNγ biomarkers, and the results of clinical trials of IFNγ-neutralizing therapeutics.

    • Fabrizio De Benedetti
    • Giusi Prencipe
    • Alexei A. Grom
    Reviews
    Nature Reviews Rheumatology
    Volume: 17, P: 678-691