Previous studies suggested the importance of intestinal tryptophan metabolism for gut homeostasis and potential systemic effects but its role in atherosclerosis remains poorly studied. Here, the authors show that the specific deletion of intestinal IDO increases gut inflammation with remote effects on atherosclerosis that can be reversed through inhibiting intestinal serotonin production.
- Mouna Chajadine
- Ludivine Laurans
- Soraya Taleb
