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Showing 1–3 of 3 results
Advanced filters: Author: Emilie Crouchet Clear advanced filters

  • The involvement of cell death pathways in the early stage of pancreatic ductal adenocarcinoma (PDAC) development, especially KRAS-dependent acinar-to-ductal metaplasia (ADM), remains to be investigated. Here, the authors find that TAK1 mediates cell survival during ADM transdifferentiation through suppression of apoptosis and necroptosis, which could be targeted for prevention and treatment of PDAC.

    • Anne T. Schneider
    • Christiane Koppe
    • Tom Luedde
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Here, using human liver chimeric mice, the authors describe perturbation of the diurnal transcriptome and epigenome of human hepatocytes during hepatitis C virus infection, affecting pathways mediating metabolic alterations, fibrosis, and cancer, and further show that the pathways remain affected in patients with advanced liver disease.

    • Atish Mukherji
    • Frank Jühling
    • Thomas F. Baumert
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.

    • Emilie Crouchet
    • Simonetta Bandiera
    • Thomas F. Baumert
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19