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Showing 1–3 of 3 results
Advanced filters: Author: Emilie J. Cosway Clear advanced filters

  • Although thymic function declines with age, the thymus also has the ability to regenerate following injury. Here, the authors demonstrate that IL-33 and type-2 innate lymphoid cells trigger the expansion of eosinophils following radiation injury, which in turn produce IL-4 to stimulate the recovery of the thymus mesenchyme during thymus regeneration.

    • Emilie J. Cosway
    • Kieran D. James
    • Graham Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Although the importance of thymic epithelial cells (TEC) in thymus physiology is established, the development of functionally diverse TEC populations remains incompletely understood. Here, using fate-mapping experiments in the embryonic thymus, the authors identify keratin19+ multipotent progenitor cells that support medullary TEC diversity in adulthood.

    • Beth Lucas
    • Andrea J. White
    • Graham Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of mTEC for specific control of multiple lineages of invariant natural killer T cells.

    • Beth Lucas
    • Andrea J. White
    • Graham Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14