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Showing 1–6 of 6 results
Advanced filters: Author: Emilio Boada-Romero Clear advanced filters

  • The T300A substitution in ATG16L is associated with Crohn’s disease risk and disrupts clearance of intracellular pathogens by autophagy. Here the authors show that the mutation impairs interaction of ATG16L with TMEM59 and disrupts unconventional TMEM-induced autophagy, an aspect of innate immunity.

    • Emilio Boada-Romero
    • Inmaculada Serramito-Gómez
    • Felipe X. Pimentel-Muiños
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Here the authors show that LC3-associated phagocytosis is initiated by various receptors, which enrich phosphatidylserine in the membrane domains proximal to the phagosome, recruiting Rubicon to the membrane for phagosome maturation.

    • Emilio Boada-Romero
    • Clifford S. Guy
    • Douglas R. Green
    ResearchOpen Access
    Nature Cell Biology
    Volume: 27, P: 1676-1687

  • The tumor environment is nutrient deficient. Here the authors show that early availability of methionine is critical for optimal T cell activation and prevents T cell dysfunction, and that dietary methionine can improve the efficacy of cancer immunotherapy in mice.

    • Piyush Sharma
    • Ao Guo
    • Douglas R. Green
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 1384-1396

  • Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein levels and function to serve compensatory and redundant roles in fine-tuning gut barrier homeostasis.

    • Karolina Slowicka
    • Inmaculada Serramito-Gómez
    • Geert van Loo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy.

    • Inmaculada Serramito-Gómez
    • Emilio Boada-Romero
    • Felipe X. Pimentel-Muiños
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Development and homeostasis are dependent on rapid cell turnover, achieved by the programmed death and subsequent engulfment and breakdown of cells, a process known as efferocytosis. Defects in efferocytosis have been linked to a wide range of diseases; ongoing research therefore aims to better understand efferocytosis processes so as to uncover new therapeutic targets.

    • Emilio Boada-Romero
    • Jennifer Martinez
    • Douglas R. Green
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 398-414