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Showing 1–3 of 3 results
Advanced filters: Author: Emilio Lecona Clear advanced filters

  • The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex from chromatin, preventing excessive priming in the lagging strand and reducing the activation of the replication stress response.

    • Sara Rodríguez-Acebes
    • Rodrigo Martín-Rufo
    • Emilio Lecona
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • USP7 deubiquitinase is now shown to prevent ubiquitination of SUMO chains of replisome proteins, thereby regulating DNA replication-fork progression and origin firing.

    • Emilio Lecona
    • Sara Rodriguez-Acebes
    • Oscar Fernandez-Capetillo
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 270-277

  • This Opinion provides insight into the potential of targeting the replication stress response in cancer and discusses the strategy of inhibiting ataxia telangiectasia and Rad3-related protein (ATR) and the need for reliable biomarkers to enable patient stratification.

    • Emilio Lecona
    • Oscar Fernandez-Capetillo
    Reviews
    Nature Reviews Cancer
    Volume: 18, P: 586-595