Nature Search

A systematic global stocktake of evidence on human adaptation to climate change

Determining progress in adaptation to climate change is challenging, yet critical as climate change impacts increase. A stocktake of the scientific literature on implemented adaptation now shows that adaptation is mostly fragmented and incremental, with evidence lacking for its impact on reducing risk.

Lea Berrang-Ford
A. R. Siders
Thelma Zulfawu Abu
Research28 Oct 2021
Nature Climate Change

Volume: 11, P: 989-1000
Correction: Corrigendum: Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

Kuan-lin Huang
Shunqiang Li
Li Ding
Amendments and CorrectionsOpen Access25 Apr 2017
Nature Communications

Volume: 8, P: 1
An ultrasensitive method for detection of cell-free RNA

A method, RARE-seq, for sensitive detection of cell-free RNAs in blood is demonstrated to have diverse clinical applications including diagnosing and characterizing human cancers, and tracking response to RNA therapeutics.

Monica C. Nesselbush
Bogdan A. Luca
Maximilian Diehn
Research16 Apr 2025
Nature

Volume: 641, P: 759-768
Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage

Conventional magnetic resonance imaging (MRI) operates at a high magnetic field strength and requires a strict access-controlled environment, making MRI often inaccessible. Here, the authors present a portable low-field MRI device that detects intracerebral hemorrhage with high accuracy.

Mercy H. Mazurek
Bradley A. Cahn
Kevin N. Sheth
ResearchOpen Access25 Aug 2021
Nature Communications

Volume: 12, P: 1-11
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation but also that its upregulation is associated with resistance to targeted therapies. This study highlights the complex and context-dependent role of APOBEC3B in lung cancer.

Deborah R. Caswell
Philippe Gui
Charles Swanton
ResearchOpen Access04 Dec 2023
Nature Genetics

Volume: 56, P: 60-73
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

Genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2 identify mucins as key host factors restricting viral infection.

Scott B. Biering
Sylvia A. Sarnik
Patrick D. Hsu
ResearchOpen Access25 Jul 2022
Nature Genetics

Volume: 54, P: 1078-1089
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Status epilepticus epidemiology—tracking a moving target

A surprisingly high rate of nonconvulsive seizures and status epilepticus is found during continuous EEG monitoring in critically ill patients. A recent analysis of data regarding hospitalization and mortality in patients with status epilepticus emphasizes the relevance not only of how status epilepticus is defined, but also of how it is detected.

Emily J. Gilmore
Lawrence J. Hirsch
News & Views23 Jun 2015
Nature Reviews Neurology

Volume: 11, P: 377-378
Computationally restoring the potency of a clinical antibody against Omicron

By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.

Thomas A. Desautels
Kathryn T. Arrildt
Daniel M. Faissol
ResearchOpen Access08 May 2024
Nature

Volume: 629, P: 878-885
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

Patient-derived xenografts recapitulate major genomic signatures and transcriptome profiles of their original tumours. Here, the authors, performing proteomic and phosphoproteomic analyses of 24 breast cancer PDX models, demonstrate that druggable candidates can be identified based on a comprehensive proteogenomic profiling.

Kuan-lin Huang
Shunqiang Li
Li Ding
ResearchOpen Access28 Mar 2017
Nature Communications

Volume: 8, P: 1-17
Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens

Using whole-genome and single-cell RNA sequencing data of patients with multiple myeloma treated with carfilzomib, lenalidomide, dexamethasone and daratumumab, Maura et al. identify distinct genomic drivers and microenvironment changes affecting outcome.

Francesco Maura
Eileen M. Boyle
Ola Landgren
Research09 Nov 2023
Nature Cancer

Volume: 4, P: 1660-1674
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Perivascular and leptomeningeal macrophages, collectively termed here parenchymal border macrophages, are shown to regulate flow dynamics of cerebrospinal fluid, implicating this cell population as new therapeutic targets in neurological diseases such as Alzheimer’s.

Antoine Drieu
Siling Du
Jonathan Kipnis
Research09 Nov 2022
Nature

Volume: 611, P: 585-593
Proteogenomics connects somatic mutations to signalling in breast cancer

Quantitative mass-spectrometry-based proteomic and phosphoproteomic analyses of genomically annotated human breast cancer samples elucidates functional consequences of somatic mutations, narrows candidate nominations for driver genes within large deletions and amplified regions, and identifies potential therapeutic targets.

Philipp Mertins
D. R. Mani
Steven A. Carr
Research25 May 2016
Nature

Volume: 534, P: 55-62
Later midline shift is associated with better post-hospitalization discharge status after large middle cerebral artery stroke

Jonathan J. Song
Rebecca A. Stafford
Charlene J. Ong
ResearchOpen Access05 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

The gut commensal Blautia producta secretes a lantibiotic that reduces colonization of the gut by the major pathogen vancomycin-resistant Enterococcus faecium, and transplantation of microbiota with high abundance of the lantibiotic gene enhances resistance to colonization in mice.

Sohn G. Kim
Simone Becattini
Eric G. Pamer
Research21 Aug 2019
Nature

Volume: 572, P: 665-669
Does birth mode modify associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome?

Sirtaj B. Singh
Juliette Madan
Noel T. Mueller
Research14 Feb 2019
International Journal of Obesity

Volume: 44, P: 23-32
Immortalized fibroblasts from NF-κB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor α after transformation by v-Ras

Maria-Emily R Gapuzan
Oliver Schmah
Thomas D Gilmore
Research18 Jul 2005
Oncogene

Volume: 24, P: 6574-6583
Cyclohexanone and metabolites exposure in critically Ill neonates and children

Suneetha Desiraju
Emily Zhao
Melania M. Bembea
Research05 Apr 2025
Pediatric Research

Volume: 98, P: 2270-2277
Bedside detection of intracranial midline shift using portable magnetic resonance imaging

Kevin N. Sheth
Matthew M. Yuen
Prantik Kundu
ResearchOpen Access07 Jan 2022
Scientific Reports

Volume: 12, P: 1-11

Search

A systematic global stocktake of evidence on human adaptation to climate change

Correction: Corrigendum: Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

An ultrasensitive method for detection of cell-free RNA

Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage

The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Status epilepticus epidemiology—tracking a moving target

Computationally restoring the potency of a clinical antibody against Omicron

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Proteogenomics connects somatic mutations to signalling in breast cancer

Later midline shift is associated with better post-hospitalization discharge status after large middle cerebral artery stroke

Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

Does birth mode modify associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome?

Immortalized fibroblasts from NF-κB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor α after transformation by v-Ras

Cyclohexanone and metabolites exposure in critically Ill neonates and children

Bedside detection of intracranial midline shift using portable magnetic resonance imaging

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