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Showing 1–3 of 3 results
Advanced filters: Author: Emily Maclary Clear advanced filters

  • Imprinted mouse X-chromosome inactivation is controlled by two long non-coding RNAs, Tsix and Xist. Here, Maclary et al. demonstrate that Tsix is dispensable during the initiation and maintenance of X-inactivation in vivo and in vitro, but required to prevent Xist expression as trophectodermal progenitors differentiate.

    • Emily Maclary
    • Emily Buttigieg
    • Sundeep Kalantry
    Research
    Nature Communications
    Volume: 5, P: 1-14

  • The X-chromosome linked long non-coding RNA, Xist, is a master regulator of the X inactivation. Here, the authors report that XistAR, an Xist anti-sense long non-coding RNA encoded within the mouse Xist gene and transcribed only from the inactive X chromosome, regulates Xistexpression.

    • Mrinal K. Sarkar
    • Srimonta Gayen
    • Sundeep Kalantry
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Here the authors show eutherian mammals co-opted the histone demethylase KDM5C during sex-chromosome evolution to induce X-chromosome inactivation by upregulating Xist expression selectively in females.

    • Milan Kumar Samanta
    • Srimonta Gayen
    • Sundeep Kalantry
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16