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Showing 1–3 of 3 results
Advanced filters: Author: Emma C. Couves Clear advanced filters

  • Biochemical and structural studies of the human MCM replicative DNA helicase complex show differences from the yeast complex and provide insights into mechanisms of double hexamer assembly on sequence-independent replication origins.

    • Florian Weissmann
    • Julia F. Greiwe
    • Alessandro Costa
    ResearchOpen Access
    Nature
    Volume: 636, P: 499-508

  • CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins. As well as how the membrane environment influences the role of CD59 in complement regulation and in host-pathogen interactions.

    • Emma C. Couves
    • Scott Gardner
    • Doryen Bubeck
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • To prevent unregulated complement activation, extracellular chaperones capture soluble precursors to the membrane attack complex (sMAC). Here, structural analysis of sMAC reveals how clusterin recognizes heterogeneous sMAC complexes and inhibits polymerization of complement protein C9.

    • Anaïs Menny
    • Marie V. Lukassen
    • Doryen Bubeck
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11