Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–13 of 13 results
Advanced filters: Author: Emma K. Farley Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes.

    • Matteo D′Antonio
    • Donate Weghorn
    • Kelly A Frazer
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • This study identifies three conserved shadow enhancers (T3, C, I) regulating notochord expression of Brachyury across vertebrates using genomic data, transgenic assays, and enhancer knockouts, which are critical for vertebrate notochord development.

    • Cassie L. Kemmler
    • Jana Smolikova
    • Alexa Burger
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • The efficacy of carbapenem antibiotics can be compromised by metallo-β-lactamases, but a high-throughput screen followed by optimization has now enabled the discovery of indole-2-carboxylates (InCs) as potent broad-spectrum metallo-β-lactamase inhibitors. The results highlight the potential of InC–carbapenem combinations for clinical use as well as mechanism-guided approaches to combatting globally disseminated antibiotic resistant mechanisms.

    • Jürgen Brem
    • Tharindi Panduwawala
    • Christopher J. Schofield
    Research
    Nature Chemistry
    Volume: 14, P: 15-24

  • Low-affinity transcription factor binding sites are prevalent across the genome, and single nucleotide changes that increase binding affinity even slightly can cause gain-of-function gene expression and phenotypes (such as polydactyly).

    • Fabian Lim
    • Joe J. Solvason
    • Emma K. Farley
    ResearchOpen Access
    Nature
    Volume: 626, P: 151-159

  • The US National Institute of Allergy and Infectious Diseases (NIAID) and the Foundation for the National Institutes of Health (FNIH) held a three-day workshop to assess the landscape of long COVID clinical studies and develop plans for the RECOVER-TLC clinical trials program.

    • Joseph J. Breen
    • Robert W. Eisinger
    • Jeanne M. Marrazzo
    News & Views
    Nature Immunology
    Volume: 26, P: 536-539

  • Here the authors identify age-associated changes in the epithelial cell compartment of the thymus that form high-density nonproductive microenvironmental niches that contribute toward thymic involution and inhibit its repair following injury.

    • Anastasia I. Kousa
    • Lorenz Jahn
    • Jarrod A. Dudakov
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 1593-1606

  • Designing accessible, interoperable and reusable software for applying deep learning to the study of gene regulation has been a challenge in genomics research. EUGENe is a toolkit that addresses this gap and streamlines end-to-end analyses.

    • Adam Klie
    • David Laub
    • Hannah Carter
    ResearchOpen Access
    Nature Computational Science
    Volume: 3, P: 946-956

  • Policies and psychological approaches often overemphasize individual agency, overlooking how socioeconomic inequality can constrain access to low-carbon alternatives. We argue that tackling these inequalities is urgent for impactful, equitable behaviour change.

    • Charlotte A. Kukowski
    • Emma E. Garnett
    Comments & Opinion
    Nature Climate Change
    Volume: 14, P: 2-4