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Showing 1–3 of 3 results
Advanced filters: Author: Emma L. Baar Clear advanced filters

  • Rapamycin extends lifespan in model organisms by targeting mTORC1, but exerts off-target side effects via inhibition of mTORC2. Here, the authors report the identification of a selective mTORC1 inhibitor, and show that it inhibits mTORC1 activity both in vitro and in vivo, with reduced side effects on glucose homeostasis, lipid metabolism, and the immune system.

    • Katherine H. Schreiber
    • Sebastian I. Arriola Apelo
    • Dudley W. Lamming
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Anthropogenic lead (Pb) has overwhelmed natural Pb sources for over a century, yet the phasing out of leaded petrol in the early 2000s has renewed hope. Here, Bridgestock et al. use Pd isotopes to reassess the origins of Pd deposited in the tropical North Atlantic and reveal a significant natural source.

    • Luke Bridgestock
    • Tina van de Flierdt
    • Hein J. W. de Baar
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12