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SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

Brian J. Willett
Joe Grove
Emma C. Thomson
ResearchOpen Access07 Jul 2022
Nature Microbiology

Volume: 7, P: 1161-1179
Genomic reconstruction of the SARS-CoV-2 epidemic in England

A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
ResearchOpen Access14 Oct 2021
Nature

Volume: 600, P: 506-511
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

The International Mouse Phenotyping Consortium (IMPC) aims to identify the function of all protein-coding genes in the mouse genome. Hayday and colleagues leverage 530 knockout lines from the IPMC to develop the 3i Project, which immunophenotypes mice and leads to the identification of new and unexpected gene influences on immune function and on the structural organization of the immune system.

Lucie Abeler-Dörner
Adam G. Laing
Adrian C. Hayday
Research16 Dec 2019
Nature Immunology

Volume: 21, P: 86-100
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
An inter-laboratory study to investigate the impact of the bioinformatics component on microbiome analysis using mock communities

Denise M. O’Sullivan
Ronan M. Doyle
Jim F. Huggett
ResearchOpen Access19 May 2021
Scientific Reports

Volume: 11, P: 1-14
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Conserved mRNA-binding proteomes in eukaryotic organisms

Comprehensive identification of mRNA-binding proteins in S. cerevisiae and C. elegans reveals their evolutionary conservation; strikingly, most components of the glycolytic pathway and proteasome are detected, thus possibly indicating an ancient mechanism for metabolic control.

Ana M Matia-González
Emma E Laing
André P Gerber
Research23 Nov 2015
Nature Structural & Molecular Biology

Volume: 22, P: 1027-1033
Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355

Bernhard Kepplinger
Lina Mardiana
Michael J. Hall
ResearchOpen Access16 Sept 2022
Scientific Reports

Volume: 12, P: 1-11
A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease

Elena Ficulle
Sarubini Kananathan
Suchira Bose
ResearchOpen Access17 Feb 2022
Scientific Reports

Volume: 12, P: 1-11
Genetic underpinnings of sociability in the general population

Janita Bralten
Nina R. Mota
Geert Poelmans
ResearchOpen Access30 May 2021
Neuropsychopharmacology

Volume: 46, P: 1627-1634
Circadian regulation in human white adipose tissue revealed by transcriptome and metabolic network analysis

Skevoulla Christou
Sophie M. T. Wehrens
Jonathan D. Johnston
ResearchOpen Access25 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Solveig K. Sieberts
Thanneer M. Perumal
Lara M. Mangravite
ResearchOpen Access12 Oct 2020
Scientific Data

Volume: 7, P: 1-11

Search

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Genomic reconstruction of the SARS-CoV-2 epidemic in England

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

An inter-laboratory study to investigate the impact of the bioinformatics component on microbiome analysis using mock communities

Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Conserved mRNA-binding proteomes in eukaryotic organisms

Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355

A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease

Genetic underpinnings of sociability in the general population

Circadian regulation in human white adipose tissue revealed by transcriptome and metabolic network analysis

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

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