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Showing 51–100 of 100 results

Advanced filters: Author: Emma Nicholson Clear advanced filters

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Analysis of whole-genome doubling (WGD) by using cancer sequencing data combined with simulations of tumor evolution suggests that there is negative selection against homozygous loss of essential genes before WGD but not after.

Saioa López
Emilia L. Lim
Nicholas McGranahan
Research05 Mar 2020
Nature Genetics

Volume: 52, P: 283-293
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Treatment with biologic therapies and the risk of cancer in patients with IBD

The efficacy of biologic therapies is proven and their use is growing worldwide; however, there is concern about their long-term safety, including the risk of developing cancer. In this Review, data available on the association of anti-tumor necrosis factor therapies and the anti-α4 integrin monoclonal antibody natalizumab with cancer in patients with IBD are discussed.

Livia Biancone
Emma Calabrese
Francesco Pallone
Reviews01 Feb 2007
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 4, P: 78-91
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

Measurements of subclonal expansion of ctDNA in the plasma before surgery may enable the prediction of future metastatic subclones, offering the possibility for early intervention in patients with non-small-cell lung cancer.

Christopher Abbosh
Alexander M. Frankell
Charles Swanton
Research13 Apr 2023
Nature

Volume: 616, P: 553-562
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer

Wu et al. utilize multiparametric analysis of early-stage human NSCLC to characterize a population of Vδ1 T cells displaying a resident memory and effector memory phenotype, which were associated with ongoing remission.

Yin Wu
Dhruva Biswas
Charles Swanton
ResearchOpen Access30 May 2022
Nature Cancer

Volume: 3, P: 696-709
Using DNA sequencing data to quantify T cell fraction and therapy response

A robust, cost-effective technique based on whole-exome sequencing data can be used to characterize immune infiltrates, relate the extent of these infiltrates to somatic changes in tumours, and enables prediction of tumour responses to immune checkpoint inhibition therapy.

Robert Bentham
Kevin Litchfield
Nicholas McGranahan
Research08 Sept 2021
Nature

Volume: 597, P: 555-560
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

Christopher Abbosh
Nicolai J. Birkbak
Charles Swanton
Research26 Apr 2017
Nature

Volume: 545, P: 446-451
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1549-1559
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma

Yuan and colleagues developed an artificial intelligence-based method to derive growth patterns and morphological features from hematoxylin and eosin-stained slides of lung adenocarcinoma samples, for improved tumor grading and patient prognostication.

Xiaoxi Pan
Khalid AbdulJabbar
David A. Moore
ResearchOpen Access10 Jan 2024
Nature Cancer

Volume: 5, P: 347-363
eTRANSAFE: data science to empower translational safety assessment

Thirteen pharmaceutical companies have shared and integrated preclinical and clinical data for creating computational resources that enhance translational drug safety assessment.

Ferran Sanz
François Pognan
David Wilkinson
Comments & Opinion14 Jun 2023
Nature Reviews Drug Discovery

Volume: 22, P: 605-606
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
The impact of the BDNF Val66Met genotype on intrusive memories following trauma exposure and in PTSD is moderated by sex and timing of trauma exposure

Emma Louise Nicholson
Michael Garry
Kim L. Felmingham
ResearchOpen Access22 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
Neoantigen-directed immune escape in lung cancer evolution

RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.

Rachel Rosenthal
Elizabeth Larose Cadieux
Andrew Kidd
Research20 Mar 2019
Nature

Volume: 567, P: 479-485
Outcomes following different upfront stem cell transplantation strategies for multiple myeloma: a statistical perspective on behalf of the Chronic Malignancies Working Party of the EBMT

Simona Iacobelli
Stefan Schönland
Nicolaus Kröger
ResearchOpen Access30 Jul 2025
Bone Marrow Transplantation

Volume: 60, P: 1361-1368
A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours

Matthew J Murray
Emma Bell
Nicholas Coleman
ResearchOpen Access15 Dec 2015
British Journal of Cancer

Volume: 114, P: 151-162
Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148
Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Francesca Chemi
Dominic G. Rothwell
Jason Lester
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1147
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Exceptional eruptive CO₂ emissions from intra-plate alkaline magmatism in the Canary volcanic archipelago

Volatile gas emissions measurements indicate the 2021 Cumbre Vieja eruption was one of the most CO₂-rich ever measured and suggest that alkaline magmatism over the lifetime of ocean island complexes could emit CO₂ at a scale comparable to large igneous provinces

Mike Burton
Alessandro Aiuppa
Nemesio M. Pérez
ResearchOpen Access12 Dec 2023
Communications Earth & Environment

Volume: 4, P: 1-10
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. They identify two loci associated with susceptibility to Barrett's esophagus.

Zhan Su
Laura J Gay
Janusz A Z Jankowski
Research09 Sept 2012
Nature Genetics

Volume: 44, P: 1131-1136
Risk factors for CAR T-cell manufacturing failure and patient outcomes in large B-cell lymphoma: a report from the UK National CAR T Panel

Vaishali Dulobdas
Amy A. Kirkwood
Sridhar Chaganti
ResearchOpen Access04 Mar 2025
Blood Cancer Journal

Volume: 15, P: 1-9
A clonal expression biomarker associates with lung cancer mortality

TRACERx Lung: Intratumoral transcriptional heterogeneity, which often hinders the development of clinically useful RNA-expression-biased biomarkers for cancer, can now be overcome with an approach for the identification of clonal expression biomarkers.

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1540-1548
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Pulmonary venous tumor cells disseminating before tumor resection are heterogeneous, predict relapse and seed future metastasis of lung cancer

Francesca Chemi
Dominic G. Rothwell
Jason Lester
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1534-1539
Publisher Correction: A clonal expression biomarker associates with lung cancer mortality

Dhruva Biswas
Nicolai J. Birkbak
Angeles Montero
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148
Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease

Philip C Robinson
Paul J Leo
Matthew A Brown
ResearchOpen Access04 May 2016
npj Genomic Medicine

Volume: 1, P: 1-6
Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study

Rajish S. K. Shil
Adam Seed
Hannah Stark
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Allogeneic hematopoietic cell transplantation for therapy-related myeloid neoplasms arising following treatment for multiple myeloma: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Kavita Raj
Diderik-Jan Eikema
Donal P. McLornan
Research12 Nov 2024
Bone Marrow Transplantation

Volume: 60, P: 220-226
The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ghorani et al. use a multiomics approach to characterize the effect of tumour mutational burden on the differentiation of CD4 and CD8 T cell subpopulations in non-small cell lung cancer.

Ehsan Ghorani
James L. Reading
Sergio A. Quezada
Research22 May 2020
Nature Cancer

Volume: 1, P: 546-561
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma

Multiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions

Khalid AbdulJabbar
Shan E. Ahmed Raza
Yinyin Yuan
Research27 May 2020
Nature Medicine

Volume: 26, P: 1054-1062
Improved outcome of COVID-19 over time in patients treated with CAR T-cell therapy: Update of the European COVID-19 multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party (IDWP) and the European Hematology Association (EHA) Lymphoma Group

Anne Mea Spanjaart
Per Ljungman
Stephan Mielke
ResearchOpen Access23 Jul 2024
Leukemia

Volume: 38, P: 1985-1991
Poor outcome of patients with COVID-19 after CAR T-cell therapy for B-cell malignancies: results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party and the European Hematology Association (EHA) Lymphoma Group

Anne Mea Spanjaart
Per Ljungman
Stephan Mielke
ResearchOpen Access08 Nov 2021
Leukemia

Volume: 35, P: 3585-3588
CAR-T cell manufacturing failures and out-of-specification products in the real-world setting: A survey from the EBMT cellular therapy and immunobiology working party

Nina Worel
Jarl E. Mooyaart
Jürgen Kuball
Correspondence15 May 2025
Bone Marrow Transplantation

Volume: 60, P: 1184-1186
Intention-to-treat outcomes utilising a stringent event definition in children and young people treated with tisagenlecleucel for r/r ALL through a national access scheme

Macarena Oporto Espuelas
Saskia Burridge
Sara Ghorashian
ResearchOpen Access15 Apr 2024
Blood Cancer Journal

Volume: 14, P: 1-10
Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party

Jesús Duque-Afonso
Jürgen Finke
Mohamad Mohty
ResearchOpen Access02 Dec 2023
Bone Marrow Transplantation

Volume: 59, P: 247-254
The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder

Emma Louise Nicholson
Michael I. Garry
Kim L. Felmingham
ResearchOpen Access28 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Comparison of fludarabine–melphalan and fludarabine–treosulfan as conditioning prior to allogeneic hematopoietic cell transplantation—a registry study on behalf of the EBMT Acute Leukemia Working Party

Jesus Duque-Afonso
Jürgen Finke
Mohamad Mohty
ResearchOpen Access14 May 2022
Bone Marrow Transplantation

Volume: 57, P: 1269-1276
Venetoclax-based salvage for management of relapsed acute leukaemia after allogeneic haematopoetic stem cell transplant: durable remissions only seen following consolidation with donor lymphocyte infusion or second transplant

Katy Smith
Dina Fathoala
Emma Nicholson
Correspondence12 Jul 2023
Bone Marrow Transplantation

Volume: 58, P: 1152-1156
Incidence of mosaicism in 1055 de novo NF2 cases: much higher than previous estimates with high utility of next-generation sequencing

D. Gareth Evans
Claire L. Hartley
Miriam J. Smith
Research05 Jul 2019
Genetics in Medicine

Volume: 22, P: 53-59
Identifying the deficiencies of current diagnostic criteria for neurofibromatosis 2 using databases of 2777 individuals with molecular testing

D. Gareth Evans
Andrew T. King
Miriam J. Smith
Research07 Dec 2018
Genetics in Medicine

Volume: 21, P: 1525-1533
Reprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism

Maomeng Tong
Ian McHardy
Jonathan Braun
ResearchOpen Access29 Apr 2014
The ISME Journal

Volume: 8, P: 2193-2206
Survival of Desulfotomaculum spores from estuarine sediments after serial autoclaving and high-temperature exposure

Louise A O'Sullivan
Erwan G Roussel
R John Parkes
ResearchOpen Access17 Oct 2014
The ISME Journal

Volume: 9, P: 922-933
Choice of commercially available CAR-T cell products for r/r DLBCL & PMBCL in Europe: a survey on behalf of the cellular therapy & immunobiology working party (CTIWP) of the EBMT

Urban Novak
Jarl E. Mooyaart
Florent Malard
Correspondence27 Aug 2024
Bone Marrow Transplantation

Volume: 59, P: 1631-1634
AusTraits, a curated plant trait database for the Australian flora

Daniel Falster
Rachael Gallagher
Kasia Ziemińska
ResearchOpen Access30 Sept 2021
Scientific Data

Volume: 8, P: 1-20
A large-scale and PCR-referenced vocal audio dataset for COVID-19

Jobie Budd
Kieran Baker
Chris Holmes
ResearchOpen Access27 Jun 2024
Scientific Data

Volume: 11, P: 1-14
Prefrontal cortex, amygdala, and threat processing: implications for PTSD

M. Alexandra Kredlow
Robert J. Fenster
Elizabeth A. Phelps
ReviewsOpen Access20 Sept 2021
Neuropsychopharmacology

Volume: 47, P: 247-259
Can pre-transplant 18F-choline positron emission tomography predict relapse following autologous stem cell transplantation in primary central nervous system lymphoma?

Thomas Millard
Fatin Sammour
Bhupinder Sharma
Correspondence05 Oct 2021
Bone Marrow Transplantation

Volume: 57, P: 113-115
p3k14c, a synthetic global database of archaeological radiocarbon dates

Darcy Bird
Lux Miranda
Jacob Freeman
ResearchOpen Access27 Jan 2022
Scientific Data

Volume: 9, P: 1-19
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis

P C Robinson
P J Leo
M A Brown
Research26 Nov 2015
Genes & Immunity

Volume: 17, P: 46-51

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